Volume 17, Number 11—November 2011
Dispatch
International Spread of MDR TB from Tugela Ferry, South Africa
Table
Locus typing for tuberculosis patient isolate according to standard nomenclature based on chromosomal locations*
Genotypic family and strain or isolate
|
Allele at MIRU-VNTR locus | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
154
|
577
|
580
|
802
|
960
|
1644
|
2059
|
2165
|
2461
|
2531
|
2687
|
2996
|
3007
|
3192
|
4348
|
|
F15/LAM4/KZN | |||||||||||||||
Patient isolate | 1 | 4 | 3 | 4 | 4 | 3 | 2 | 2 | 2 | 6 | 1 | 5 | 3 | 3 | 2 |
605 (reference) | 1 | 4 | 2 | 4 | 4 | 3 | 2 | 2 | 2 | 6 | 1 | 5 | 3 | 3 | 2 |
1435 | 1 | 4 | 2 | 5 | 4 | 3 | 2 | 2 | 2 | 6 | 1 | 5 | 3 | 3 | 2 |
R506 | 1 | 4 | 2 | 3 | 3 | 3 | 2 | 2 | 2 | 6 | 1 | 4 | 3 | 3 | 2 |
V2475 | 1 | 4 | 2 | 3 | 3 | 3 | 2 | 2 | 2 | 6 | 1 | 4 | 3 | 3 | 2 |
4207 | 1 | 4 | 2 | 3+4 | 3+4 | 3 | 2 | 2 | 2 | 6 | 1 | 4+5 | 3 | 3 | 2 |
F11/LAM | |||||||||||||||
F11 | 2 | 4 | 2 | 3 | 3 | 3 | 2 | 2 | 2 | 6 | 1 | 4 | 3 | 3 | 2 |
*Patient’s isolate most closely matches F15/LAM4/KZN605 reference strain by a single locus variation, a genetic distance equal to or lower than that separating other known F15/LAM4/KZN strains (i.e., 1–3 locus variations). MIRU-VNTR, mycobacterial interspersed repetitive units–variable number tandem repeats.