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Volume 17, Number 12—December 2011
Research

Isolation of Prion with BSE Properties from Farmed Goat

John SpiropoulosComments to Author , Richard Lockey, Rosemary E. Sallis, Linda A. Terry, Leigh Thorne, Thomas M. Holder, Katy E. Beck, and Marion M. Simmons
Author affiliations: Animal Health and Veterinary Laboratories Agency, Weybridge, Surrey, UK

Main Article

Figure 5

Lesion profiles from VM mice after second passage of the suspected case, serial passage of an ovine bovine spongiform encephalopathy (BSE) source, and a 301V control. Profiles were made on the basis of the lesion score, which is the quantification of transmissible spongiform encephalopathy–specific vacuolation in 9 neuroanatomical gray matter areas: G1, dorsal medulla nuclei; G2, cerebellar cortex of the folia including the granular layer, adjacent to the fourth ventricle; G3, cortex of the supe

Figure 5. Lesion profiles from VM mice after second passage of the suspected case, serial passage of an ovine bovine spongiform encephalopathy (BSE) source, and a 301V control. Profiles were made on the basis of the lesion score, which is the quantification of transmissible spongiform encephalopathy–specific vacuolation in 9 neuroanatomical gray matter areas: G1, dorsal medulla nuclei; G2, cerebellar cortex of the folia including the granular layer, adjacent to the fourth ventricle; G3, cortex of the superior colliculus; G4, hypothalamus; G5, thalamus; G6, hippocampus; G7, septal nuclei of the paraterminal body; G8, cerebral cortex (at the level of G4 and G5); G9, cerebral cortex (at the level of G7). At least 9 clinically and histopathologically positive mice contributed to each profile. Error bars indicate SEM.

Main Article

Page created: November 30, 2011
Page updated: November 30, 2011
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