Volume 17, Number 12—December 2011
A Pilot Study of Host Genetic Variants Associated with Influenza-associated Deaths among Children and Young Adults1
|Outcome||Estimated odds ratio (95% CI)
|Low producing MBL2 haplotype†||Intermediate or high producing MBL2 haplotype‡||p value|
|MRSA, n = 8||7.1 (1.6–32.1)||Referent||0.02|
|Staphylococcus aureus, n = 13||3.0 (0.8–11.2)||Referent||0.11|
|Bacterial co-infection, n = 22||2.7 (0.9–8.6)||Referent||0.10|
*MBL2, mannose-binding lectin gene; MRSA, methicillin-resistant Staphylococcus aureus.
†includes MBL2 haplotypes O/O and XA/O.
‡includes MBL2 intermediate producer haplotypes XA/XA and YA/O and high producer haplotypes XA/YA and YA/YA.
1Portions of this study were presented at the Options for the Control of Influenza VII meeting, September 3–7, 2010, Hong Kong.