Volume 17, Number 12—December 2011
Research
A Pilot Study of Host Genetic Variants Associated with Influenza-associated Deaths among Children and Young Adults1
Jill M. Ferdinands
, Amy M. Denison, Nicole F. Dowling, Heather A. Jost, Marta L. Gwinn, Lindy Liu, Sherif R. Zaki, and David K. Shay
, Amy M. Denison, Nicole F. Dowling, Heather A. Jost, Marta L. Gwinn, Lindy Liu, Sherif R. Zaki, and David K. Shay
Table 3
Associations between MBL2 haplotypes and invasive bacterial co-infection in fatal influenza in children and young adults, United States, 1998–99 through 2007–08 influenza seasons*
| Outcome | Estimated odds ratio (95% CI) |
||
|---|---|---|---|
| Low producing MBL2 haplotype† | Intermediate or high producing MBL2 haplotype‡ | p value | |
| MRSA, n = 8 | 7.1 (1.6–32.1) | Referent | 0.02 |
| Staphylococcus aureus, n = 13 | 3.0 (0.8–11.2) | Referent | 0.11 |
| Bacterial co-infection, n = 22 | 2.7 (0.9–8.6) | Referent | 0.10 |
*MBL2, mannose-binding lectin gene; MRSA, methicillin-resistant Staphylococcus aureus.
†includes MBL2 haplotypes O/O and XA/O.
‡includes MBL2 intermediate producer haplotypes XA/XA and YA/O and high producer haplotypes XA/YA and YA/YA.
1Portions of this study were presented at the Options for the Control of Influenza VII meeting, September 3–7, 2010, Hong Kong.
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