Volume 17, Number 12—December 2011
Research
A Pilot Study of Host Genetic Variants Associated with Influenza-associated Deaths among Children and Young Adults1
, Amy M. Denison, Nicole F. Dowling, Heather A. Jost, Marta L. Gwinn, Lindy Liu, Sherif R. Zaki, and David K. Shay
Table 4
Characteristics of 8 children and young adults who died of influenza and had invasive methicillin-resistant Staphylococcus aureus co-infection, United States, 1998–99 through 2007–08 influenza seasons
| Patient age, y/sex | Season | Influenza type | Previous conditions | Sudden death* | MBL2 haplotype† | MBL production haplotype‡ | MBL2 structural variant |
|---|---|---|---|---|---|---|---|
| 29/M | 2004–05 | A | None | Yes | YA/O | Intermediate | rs1800450 A/G |
| 14/M | 2006–07 | A | None | No | XA/YA | High | None |
| 11/F | 2006–07 | B | None | Yes | YA/YA | High | None |
| 13/M | 2006–07 | B | None | Yes | XA/O | Low | rs1800450 A/G |
| 12/F | 2006–07 | B | None | No | O/O | Low | rs1800450 A/A |
| 8/F | 2007–08 | A | Asthma | Yes | XA/O | Low | rs1800450 A/G |
| 18/M | 2007–08 | A | Asthma | Yes | XA/O | Low | rs1800450 A/G |
| 32/M | 2007–08 | B | Asthma | No | XA/YA | High | None |
*Sudden death is defined as death occurring less than 3 days after symptom onset. MBL2, mannose-binding lectin gene.
†Per common designation for MBL2, A refers to the wild-type structural allele, O refers to any of the 3 variant structural alleles, and O/O refers to any combination of structural variant alleles. Y refers to the wild-type allele and X to the variant allele at promoter locus rs7096206 (the X/Y variant).
‡Low mannose-binding lectin (MBL) producers included MBL2 haplotypes O/O and XA/O. Intermediate producers included MBL2 haplotypes XA/XA and YA/O. High producers included MBL2 haplotypes XA/YA and YA/YA.
1Portions of this study were presented at the Options for the Control of Influenza VII meeting, September 3–7, 2010, Hong Kong.