Volume 17, Number 2—February 2011
Research
Possible Increased Pathogenicity of Pandemic (H1N1) 2009 Influenza Virus upon Reassortment
Eefje J.A. Schrauwen, Sander Herfst, Salin Chutinimitkul, Theo M. Bestebroer, Guus F. Rimmelzwaan, Albert D.M.E. Osterhaus, Thijs Kuiken, and Ron A.M. Fouchier
Table 1
Predominant virus genome composition upon in vitro selection of mixtures of pandemic (H1N1) 2009–seasonal (H1N1) and pandemic (H1N1)–seasonal (H3N2) influenza virus reassortants*
| Replicates | PB2 | PB1 | PA | HA | NP | NA | M | NS |
|---|---|---|---|---|---|---|---|---|
| Pandemic (H1N1) 2009–seasonal (H1N1) 1 | sH1 | pH1 | sH1 | pH1 | pH1 | pH1 | pH1 | pH1 |
| Pandemic (H1N1) 2009–seasonal (H1N1) 2 | sH1 | pH1 | sH1 | pH1 | pH1 | pH1 | pH1 | pH1 |
| Pandemic (H1N1) 2009–seasonal (H1N1) 3 | sH1 | pH1 | pH1 | pH1 | pH1 | pH1 | pH1 | pH1 |
| Pandemic (H1N1) 2009–seasonal (H1N1) 4 | pH1 | pH1 | pH1 | pH1 | pH1 | pH1 | pH1 | pH1 |
| Pandemic (H1N1) 2009–seasonal (H3N2) 1 | pH1 | sH3 | pH1 | pH1 | pH1 | sH3 | pH1 | pH1 |
| Pandemic (H1N1) 2009–seasonal (H3N2) 2 | pH1 | pH1 | pH1 | pH1 | pH1 | sH3 | pH1 | pH1 |
| Pandemic (H1N1) 2009–seasonal (H3N2) 3 | pH1 | sH3 | pH1 | pH1 | pH1 | sH3 | pH1 | pH1 |
| Pandemic (H1N1) 2009–seasonal (H3N2) 4 | pH1 | sH3 | pH1 | pH1 | pH1 | sH3 | pH1 | pH1 |
*PB, basic polymerase; PA, acidic polymerase; HA, hemagglutinin; NP, nucleoprotein; NA, neuraminidase; M, matrix; NS, nonstructural; sH1, seasonal influenza A virus (H1N1); pH1, pandemic (H1N1) 2009 virus; sH3, seasonal influenza A (H3N2) virus.
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