Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 17, Number 5—May 2011

Severe Imported Plasmodium falciparum Malaria, France, 1996–2003

Elise Seringe, Marc Thellier, Arnaud Fontanet, Fabrice Legros, Olivier Bouchaud, Thierry Ancelle, Eric Kendjo, Sandrine Houze, Jacques Le Bras, Martin Danis, Rémy DurandComments to Author , and for the French National Reference Center for Imported Malaria Study Group
Author affiliations: Author affiliations: University Pierre et Marie Curie, Paris, France (E. Seringe, M. Thellier, M. Danis); Groupe Hospitalier Pitié-Salpĕtrière, Paris (E. Seringe, M. Thellier, M. Danis); Centre National de Référence du Paludisme, Paris (M. Thellier, F. Legros, E. Kendjo, S. Houze, J. Le Bras, M. Danis, R. Durand); Institut Pasteur, Paris (E. Seringe, A. Fontanet); Conservatoire National des Arts et Métiers, Paris (A. Fontanet); Hôpital Avicenne, Bobigny, France (O. Bouchaud, R. Durand); Hôpital Cochin, Paris (T. Ancelle)

Main Article

Table 1

Criteria used before 2000 to define severe malaria, 1990 World Health Organization definition

Major criteria
Unrousable coma
Glasgow Coma Scale score of <9
Repeated generalized seizures
Circulatory collapse, systolic blood pressure <80 mmHg
despite adequate volume repletion
Pulmonary edema with presence of criteria for acute
respiratory distress syndrome or acute lung injury
Spontaneous bleeding and/or disseminated intravascular
Acidemia, pH <7.35, or acidosis, serum bicarbonate <15
Severe anemia, hemoglobin <5 g/dL
Renal impairment, serum creatinine >265 μmol/L
Hypoglycemia, blood glucose, <2.2 mmol/L
Macroscopic hemoglobinuria (if unequivocally related to
Minor criteria
Impaired consciousness but rousable
Extreme weakness
Temperature >40°C
Parasitemia >5%
Jaundice or total bilrubin >50 μmol/L

Main Article

1Additional members of the French National Reference Center for Imported Malaria Study Group who contributed data are listed in the Technical Appendix.

Page created: September 01, 2011
Page updated: September 01, 2011
Page reviewed: September 01, 2011
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.