Volume 17, Number 6—June 2011
Invasive Group A Streptococcal Infection and Vaccine Implications, Auckland, New Zealand
|Diagnosis†||Age group, y
||All ages, no. (%),‡ N = 225||p value§|
|0–14, n = 36
||>15, n = 189
|Skin and soft tissue infection¶||11||0||86||8||97 (43)||0.14|
|Bacteremia only||7||38||31||19||38 (16)||0.63|
|Bone infection||6||0||20||0||26 (12)||0.39|
|Pneumonia and other respiratory infection||12||13||12||0||24 (11)||0.0001|
|Necrotizing fasciitis**||1||0||19||15||20 (9)||0.21|
|Pelvic infection/peripartum‡‡||0||0||12||0||12 (5)|
*CFR, case-fatality rate; GAS, group A streptococcal; STSS, streptococcal toxic shock syndrome.
†Patients may have had >1 diagnosis, with the exception of bacteremia without a source. Other conditions (not shown) included 4 upper airway infections 6 ear/nose/throat infections, 5 central nervous system infections, 4 cases of peritonitis, 3 urinary tract infections, and 2 hemodialysis vascular access infections. No deaths occurred in this group.
‡Overall CFR 10% (22/225).
§p value calculated by using Fisher exact test, a test of difference between age groups.
¶Includes cellulitis (n = 79), cutaneous abscess, boil, lymphadenitis, myositis, bursitis, infected burn, infected scabies, and infected ulcer with evidence of documented bacteremia.
#STSS confirmed and probable (n = 3).
**Five patients had STSS and NF; 1/5 died (20% CFR).
††Three of 6 were community deaths in infants <1 y of age.
‡‡Includes pregnancy-related (n = 6) endometritis and infected products, urinary tract infection/chorioamnionitis, and wound problems.