Volume 17, Number 6—June 2011
Dispatch
Invasive Streptococcus pneumoniae in Children, Malawi, 2004–2006
Table 2
Antimicrobial drug susceptibilities of Streptococcus pneumoniae isolates from children at Queen Elizabeth Central Hospital, Blantyre, Malawi, 2004–2006*
Antimicrobial drug | MIC, mg/L |
No. (%) isolates* |
Breakpoint values |
||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Minimum | Maximum | MIC50 | MIC90 | GM | S | I | R | S | I | R | |||
Benzyl penicillin | |||||||||||||
Meningitis breakpoints | <0.016 | 0.500 | <0.016 | 0.094 | 0.025 | 156 (90) | – | 18 (10) | <0.06 | – | >0.12 | ||
Nonmeningitis breakpoints | <0.016 | 0.500 | <0.016 | 0.094 | 0.025 | 176 (100) | 0 | 0 | <2.0 | 4.0 | >8.0 | ||
Ceftriaxone | |||||||||||||
Meningitis breakpoints | <0.016 | 0.250 | <0.016 | 0.064 | 0.025 | 176 (100) | 0 | 0 | <0.5 | 1.0 | >2.0 | ||
Nonmeningitis breakpoints | <0.016 | 0.500 | <0.016 | 0.094 | 0.025 | 176 (100) | 0 | 0 | <1.0 | 2.0 | >4.0 | ||
Chloramphenicol | 0.380 | 30.000 | 3.000 | 25.000 | 4.660 | 129 (73) | – | 47 (27) | <4.0 | – | >8.0 |
*MIC50, 50% MIC; MIC90, 90% MIC; GM, geometric mean; S, susceptible; I, intermediate; R, resistant; –, no intermediate resistance values for these antimicrobial drugs, according to Clinical and Laboratory Standards Institute definitions.