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Volume 17, Number 9—September 2011
Dispatch

Wild Rodents and Novel Human Pathogen Candidatus Neoehrlichia mikurensis, Southern Sweden

Martin AnderssonComments to Author  and Lars Råberg
Author affiliations: Author affiliation: Lund University, Lund, Sweden

Main Article

Figure 2

Phylogenetic network of 16s rRNA sequences (1,231 bp) from Candidatus Neoehrlichia mikurensis, southern Sweden, 2008. Black nodes indicate intermediate inferred sequences on the most parsimonious route between observed sequences. Numbers on branches represents mutations, numbered according to nucleotide position in the alignment. The sequence obtained in this study is shown in boldface and is identical with sequences from human patients in Germany (3) and Switzerland (2). The Japanese reference

Figure 2. Phylogenetic network of 16s rRNA sequences (1,231 bp) from Candidatus Neoehrlichia mikurensis, southern Sweden, 2008. Black nodes indicate intermediate inferred sequences on the most parsimonious route between observed sequences. Numbers on branches represents mutations, numbered according to nucleotide position in the alignment. The sequence obtained in this study is shown in boldface and is identical with sequences from human patients in Germany (3) and Switzerland (2). The Japanese reference strain TK4456 (7) showed 99.2% similarity with our sequence, and the North American Candidatus N. lotori strain (12) showed 98.3% similarity.

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References
  1. Welinder-Olsson  C, Kjellin  E, Vaht  K, Jacobsson  S, Wennerås  C. First case of human “Candidatus Neoehrlichia mikurensis” infection in a febrile patient with chronic lymphocytic leukemia. J Clin Microbiol. 2010;48:1956–9. DOIPubMedGoogle Scholar
  2. Fehr  JS, Bloemberg  GV, Ritter  C, Hombach  M, Lüscher  TF, Weber  R, Septicemia caused by tick-borne bacterial pathogen Candidatus Neoehrlichia mikurensis. Emerg Infect Dis. 2010;16:1127–9. DOIPubMedGoogle Scholar
  3. von Loewenich  FD, Geißdörfer  W, Disqué  C, Matten  J, Schett  G, Sakka  SG, Detection of “Candidatus Neoehrlichia mikurensis” in two patients with severe febrile illnesses: evidence for a European sequence variant. J Clin Microbiol. 2010;48:2630–5. DOIPubMedGoogle Scholar
  4. Schouls  LM, Van de Pol  I, Rijpkema  SG, Schot  CS. Detection and identification of Ehrlichia, Borrelia burgdorferi sensu lato, and Bartonella species in Dutch Ixodes ricinus ticks. J Clin Microbiol. 1999;37:2215–22.PubMedGoogle Scholar
  5. Alekseev  AN, Dubinina  HV, Van de Pol  I, Schouls  LM. Identification of Ehrlichia spp, and Borrelia burgdorferi in Ixodes ticks in the Baltic regions of Russia. J Clin Microbiol. 2001;39:2237–42. DOIPubMedGoogle Scholar
  6. Brouqui  P, Sanogo  YO, Caruso  G, Merola  F, Raoult  D. Candidatus Ehrlichia walkerii—a new Ehrlichia detected in Ixodes ricinus tick collected from asymptomatic humans in northern Italy. Ann N Y Acad Sci. 2003;990:134–40. DOIPubMedGoogle Scholar
  7. Kawahara  M, Rikihisa  Y, Isogai  E, Takahashi  M, Misumi  H, Suto  C, Ultrastructure and phylogenetic analysis of “Candidatus Neoehrlichia mikurensis” in the family Anaplasmataceae, isolated from wild rats and found in Ixodes ovatus ticks. Int J Syst Evol Microbiol. 2004;54:1837–43. DOIPubMedGoogle Scholar
  8. Dugan  VG, Gaydos  JK, Stallknecht  DE, Little  SE, Beall  AD, Mead  DG, Detection of Ehrlichia spp. in raccoons (Procyon lotor) from Georgia. Vector Borne Zoonotic Dis. 2005;5:162–71. DOIPubMedGoogle Scholar
  9. Beninati  T, Piccolo  G, Rizzoli  A, Genchi  C, Bandi  C. Anaplasmataceae in wild rodents and roe deer from Trento province (northern Italy). Eur J Clin Microbiol Infect Dis. 2006;25:677–8. DOIPubMedGoogle Scholar
  10. Tabara  K, Arai  S, Kawabuchi  T, Itagaki  A, Ishihara  C, Satoh  H, Molecular survey of Babesia microti, Ehrlichia species and Candidatus Neoehrlichia mikurensis in wild rodents from Shimane Prefecture, Japan. Microbiol Immunol. 2007;51:359–67.PubMedGoogle Scholar
  11. Bandelt  H-J, Forster  P, Röhl  A. Median-joining networks for inferring intraspecific phylogenies. Mol Biol Evol. 1999;16:37–48.PubMedGoogle Scholar
  12. Yabsley  MJ, Murphy  SM, Luttrell  MP, Wilcox  BR, Ruckdeschel  C. Raccoons (Procyon lotor), but not rodents, are natural and experimental hosts for an ehrlichial organism related to “Candidatus Neoehrlichia mikurensis.”. Vet Microbiol. 2008;131:301–8. DOIPubMedGoogle Scholar
  13. Spitalská  E, Boldis  V, Kostanova  Z, Kocianova  E, Stefanidesova  K. Incidence of various tick-borne microorganisms in rodents and ticks of Central Slovakia. Acta Virol. 2008;52:175–9.PubMedGoogle Scholar
  14. Dumler  JS, Barbet  AF, Bekker  CP, Dasch  GA, Palmer  GH, Ray  SC, Reorganization of genera in the families Rickettsiaceae and Anaplasmataceae in the order Rickettsiales: unification of some species of Ehrlichia with Anaplasma, Cowdria with Ehrlichia and Ehrlichia with Neorickettsia, descriptions of six new species combinations and designation of Ehrlichia equi and “HGE agent” as subjective synonyms of Ehrlichia phagocytophila. Int J Syst Evol Microbiol. 2001;51:2145–65. DOIPubMedGoogle Scholar
  15. Tälleklint  L, Jaenson  TG. Transmission of Borrelia burgdorferi s.l from mammal reservoirs to the primary vector of Lyme borreliosis, Ixodes ricinus (Acari: ixodidae), in Sweden. J Med Entomol. 1994;31:880–6.PubMedGoogle Scholar

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