TY - JOUR AU - Al Akhrass, Fadi AU - Hachem, Ray AU - Mohamed, Jamal A. AU - Tarrand, Jeffrey AU - Kontoyiannis, Dimitrios P. AU - Chandra, Jyotsna AU - Ghannoum, Mahmoud AU - Haydoura, Souha AU - Chaftari, Ann Marie AU - Raad, Issam T1 - Central Venous Catheter–associated Nocardia Bacteremia in Cancer Patients T2 - Emerging Infectious Disease journal PY - 2011 VL - 17 IS - 9 SP - 1651 SN - 1080-6059 AB - Central venous catheters, often needed by cancer patients, can be the source of Nocardia bacteremia. We evaluated the clinical characteristics and outcomes of 17 cancer patients with Nocardia bacteremia. For 10 patients, the bacteremia was associated with the catheter; for the other 7, it was a disseminated infection. N. nova complex was the leading cause of bacteremia. Nocardia promoted heavy biofilm formation on the surface of central venous catheter segments tested in an in vitro biofilm model. Trimethoprim- and minocycline-based lock solutions had potent in vitro activity against biofilm growth. Patients with Nocardia central venous catheter–associated bloodstream infections responded well to catheter removal and antimicrobial drug therapy, whereas those with disseminated bacteremia had poor prognoses. KW - Nocardia KW - bacteremia KW - catheter related KW - disseminated KW - immunocompromised KW - biofilm KW - cancer KW - central venous catheter KW - antimicrobial KW - bacteria KW - research KW - United States DO - 10.3201/eid1709.101810 UR - https://wwwnc.cdc.gov/eid/article/17/9/10-1810_article ER - End of Reference