TY - JOUR AU - Ducatez, Mariette F. AU - Hause, Ben AU - Stigger-Rosser, Evelyn AU - Darnell, Daniel AU - Corzo, Cesar AU - Juleen, Kevin AU - Simonson, Randy AU - Brockwell-Staats, Christy AU - Rubrum, Adam AU - Wang, David AU - Webb, Ashley AU - Crumpton, Jeri-Carol AU - Lowe, James AU - Gramer, Marie AU - Webby, Richard J. T1 - Multiple Reassortment between Pandemic (H1N1) 2009 and Endemic Influenza Viruses in Pigs, United States T2 - Emerging Infectious Disease journal PY - 2011 VL - 17 IS - 9 SP - 1624 SN - 1080-6059 AB - As a result of human-to-pig transmission, pandemic influenza A (H1N1) 2009 virus was detected in pigs soon after it emerged in humans. In the United States, this transmission was quickly followed by multiple reassortment between the pandemic virus and endemic swine viruses. Nine reassortant viruses representing 7 genotypes were detected in commercial pig farms in the United States. Field observations suggested that the newly described reassortant viruses did not differ substantially from pandemic (H1N1) 2009 or endemic strains in their ability to cause disease. Comparable growth properties of reassortant and endemic viruses in vitro supported these observations; similarly, a representative reassortant virus replicated in ferrets to the same extent as did pandemic (H1N1) 2009 and endemic swine virus. These novel reassortant viruses highlight the increasing complexity of influenza viruses within pig populations and the frequency at which viral diversification occurs in this ecologically important viral reservoir. KW - zoonoses KW - swine influenza KW - influenza KW - endemic KW - pandemic KW - reassortant KW - multiple reassortment KW - viruses KW - pigs United States KW - research KW - United States DO - 10.3201/eid1709.110338 UR - https://wwwnc.cdc.gov/eid/article/17/9/11-0338_article ER - End of Reference