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Volume 18, Number 1—January 2012
Research

Modeling Insights into Haemophilus influenzae Type b Disease, Transmission, and Vaccine Programs

Michael L. Jackson1Comments to Author , Charles E. Rose, Amanda Cohn, Fatima Coronado, Thomas A. Clark, Jay D. Wenger, Lisa Bulkow, Michael G. Bruce, Nancy E. Messonnier, and Thomas W. Hennessy
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA

Main Article

Table

Estimated annual prevaccination force of infection from Hib infectious persons to persons with susceptible, no-antibody status and estimated annual prevalence of Hib colonization in 3 modeled populations, stratified by age group*

Susceptible population, age group, y Hib infections caused by infectious persons/1,000 susceptible persons, by age group, y
Total no. cases
0–1 2–4 5–9 >10
United States
0–1 0.2 24.3 11.6 0.2 36.3
2–4 0.1 77.4 1.4 0.3 79.2
5–9 10.1 136.2 15.5 2.0 163.8
>10 7.0 78.5 9.2 0.8 95.5
Prevalence 1.1% 2.9% 5.3% 3.2% NA
England and Wales
0–1 0.6 15.4 10.7 1.7 28.4
2–4 3.1 62.8 11.2 1.9 79.0
5–9 10.1 133.6 16.8 1.9 162.5
>10 6.6 78.4 8.4 2.4 95.8
Prevalence 1.0% 3.0% 4.9% 3.0% NA
Alaska Natives
0–1 109.5 5.8 52.3 1.2 168.8
2–4 28.4 15.8 49.2 5.4 98.8
5–9 28.9 144.3 357.8 5.9 536.9
>10 28.4 21.7 80.3 64.7 195.1
Prevalence 5.2% 3.9% 9.9% 4.5% NA

*Values are no. infections except as indicated. Data are based on Hib simulation model. Hib, Haemophilus influenzae type b; NA, not applicable.

Main Article

1Current affiliation: Group Health Research Institute, Seattle, Washington, USA.

Page created: December 21, 2011
Page updated: December 21, 2011
Page reviewed: December 21, 2011
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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