TY - JOUR
AU - Lipsitz, Rebecca
AU - Garges, Susan
AU - Aurigemma, Rosemarie
AU - Baccam, Prasith
AU - Blaney, David
AU - Cheng, Allen
AU - Currie, Bart
AU - Dance, David
AU - Gee, Jay
AU - Larsen, Joseph
AU - Limmathurotsakul, Direk
AU - Morrow, Meredith
AU - Norton, Robert
AU - O’Mara, Elizabeth
AU - Peacock, Sharon
AU - Pesik, Nicki
AU - Rogers, L. Paige
AU - Schweizer, Herbert
AU - Steinmetz, Ivo
AU - Tan, Gladys
AU - Tan, Patrick
AU - Wiersinga, W. Joost
AU - Wuthiekanun, Vanaporn
AU - Smith, Theresa
T1 - Workshop on Treatment of and Postexposure Prophylaxis for Burkholderia pseudomallei and B. mallei Infection, 2010
T2 - Emerging Infectious Disease journal
PY - 2012
VL - 18
IS - 12
SN - 1080-6059
AB - The US Public Health Emergency Medical Countermeasures Enterprise convened subject matter experts at the 2010 HHS Burkholderia Workshop to develop consensus recommendations for postexposure prophylaxis against and treatment for Burkholderia pseudomallei and B. mallei infections, which cause melioidosis and glanders, respectively. Drugs recommended by consensus of the participants are ceftazidime or meropenem for initial intensive therapy, and trimethoprim/sulfamethoxazole or amoxicillin/clavulanic acid for eradication therapy. For postexposure prophylaxis, recommended drugs are trimethoprim/sulfamethoxazole or co-amoxiclav. To improve the timely diagnosis of melioidosis and glanders, further development and wide distribution of rapid diagnostic assays were also recommended. Standardized animal models and B. pseudomallei strains are needed for further development of therapeutic options. Training for laboratory technicians and physicians would facilitate better diagnosis and treatment options.
KW - Burkholderia pseudomallei
KW - melioidosis
KW - Burkholderia mallei
KW - glanders
KW - drug therapy
KW - postexposure prophylaxis
KW - ceftazidime
KW - carbapenems
KW - trimethoprim/sulfamethoxazole
KW - combination
KW - amoxicillin/potassium clavulanate
KW - clavulanic acid bacteria
KW - antibiotic
KW - antibacterial drugs
KW - antimicrobial drugs
KW - bacteria
KW -
DO - 10.3201/eid1812.120638
UR - https://wwwnc.cdc.gov/eid/article/18/12/12-0638_article
ER - End of Reference