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Volume 18, Number 3—March 2012
Dispatch

Escherichia coli O104:H4 Infections and International Travel

David C. Alexander, Weilong Hao, Matthew W. Gilmour, Sandra Zittermann, Alicia Sarabia, Roberto G. Melano, Analyn Peralta, Marina Lombos, Keisha Warren, Yuri Amatnieks, Evangeline Virey, Jennifer H. Ma, Frances B. Jamieson, Donald E. Low, and Vanessa AllenComments to Author 
Author affiliations: Public Health Ontario, Toronto, Ontario, Canada (D.C. Alexander, W. Hao, S. Zittermann, R.G. Melano, A. Peralta, M. Lombos, K. Warren, J.H. Ma, F.B. Jamieson, D.E. Low, V.G. Allen); University of Toronto, Toronto (D.C. Alexander, W. Hao, R.G. Melano, F.B. Jamieson, D.E. Low, V.G. Allen); Mount Sinai Hospital, Toronto (W. Hao, K. Warren, D.E. Low); Public Health Agency of Canada, Winnipeg, Manitoba, Canada (M.W. Gilmour); Credit Valley Hospital, Mississauga, Ontario, Canada (A. Sarabia, Y. Amatnieks, E. Virey)

Main Article

Table

Virulence loci of ON-2011, ON-2010, and EAEC strain 55989*

Gene product Function Presence in ON-2011 Presence in ON-2010 Presence in EAEC 55989
STEC
stx1 Shiga toxin 1 –-
stx2 Shiga toxin 2 +
EHEC-hlyA EHEC hemolysin
cdt(I–V) Cytolethal distending toxin
subAB Subtilase cytotoxin
espP Serine protease EspP
eae Intimin
iha Iha (IrgA homologue adhesin) + Partial (5′ end 21%) +
lpfAO26 Structural subunit of LPF of STEC O26 + + +
lpfAO113 Structural subunit of LPF of STEC O113 + + +
lpfAO157–OI141 Structural subunit of LPF of STEC O157:H7 (encoded on O island 141)
lpfAO157–OI154 Structural subunit of LPF of STEC O157:H7 (encoded on O island 154)
saa Saa (STEC autoagglutinating adhesin)
sfpA Structural subunit of Sfp fimbriae
ter cluster Tellurite resistance +
irp2 Component of iron uptake system on HPI + + +
fyuA Component of iron uptake system on HPI + + +
EAEC
aatA EAEC virulence plasmid (pAA) + + +
aggA Pilin subunit of aggregative adherence fimbriae I (AAF/I) +
agg3A Pilin subunit of AAF/III + +
aggR Transcriptional regulator AggR + + +
aap Dispersin + + +
set1 Shigella enterotoxin 1 + + +
pic Pic (protein involved in intestinal colonization) + + +
astA EAEC heat-stable enterotoxin 1 (EAST1) + +
EPEC
bfpA Bundle-forming pili
ETEC
elt Heat-labile enterotoxin (LT)
estla Heat-stable enterotoxin (STIa)
estlb Heat-stable enterotoxin (STIb)
EIEC
ial Invasive plasmid (pInv)

*Derived from (11). EAEC, enteroaggregative Escherichia coli; STEC, Shiga- toxigenic E. coli; EHEC, enterohemorrhagic; LPF, long polar fimbriae; EPEC, enteropathogenic E. coli; ETEC, enterotoxigenic E. coli; EIEC, enterinvasive E. coli.

Main Article

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