TY - JOUR AU - Johnson, James AU - Nicolas-Chanoine, Marie-Hélène AU - DebRoy, Chitrita AU - Castanheira, Mariana AU - Robicsek, Ari AU - Hansen, Glen AU - Weissman, Scott AU - Urban, Carl AU - Platell, Joanne AU - Trott, Darren AU - Zhanel, George AU - Clabots, Connie AU - Johnston, Brian AU - Kuskowski, Michael T1 - Comparison of Escherichia coli ST131 Pulsotypes, by Epidemiologic Traits, 1967–2009 T2 - Emerging Infectious Disease journal PY - 2012 VL - 18 IS - 4 SP - 598 SN - 1080-6059 AB - Escherichia coli sequence type 131 (ST131), an emerging disseminated public health threat, causes multidrug-resistant extraintestinal infections. Among 579 diverse E. coli ST131 isolates from 1967–2009, we compared pulsotypes (>94% similar XbaI pulsed-field gel electrophoresis profiles) by collection year, geographic origin, source, and antimicrobial drug–resistance traits. Of 170 pulsotypes, 65 had >2 isolates and accounted for 85% of isolates. Although extensively dispersed geographically, pulsotypes were significantly source specific (e.g., had little commonality between humans vs. foods and food animals). The most prevalent pulsotypes were associated with recent isolation, humans, and antimicrobial drug resistance. Predominant pulsotype 968 was associated specifically with fluoroquinolone resistance but not with extended-spectrum β-lactamase production or blaCTX-M-15. Thus, several highly successful antimicrobial drug–resistant lineages within E. coli ST131 have recently emerged and diffused extensively among locales while maintaining a comparatively restricted host/source range. Identification of factors contributing to this behavior of ST131 could help protect public health. KW - Escherichia coli infections KW - ST131 KW - CTX-M-15 KW - fluoroquinolone resistance KW - extended-spectrum beta-lactamases KW - pulsed-field gel electrophoresis KW - bacteria KW - sequence type 131 KW - antimicrobial resistance KW - sequence typing DO - 10.3201/eid1804.111627 UR - https://wwwnc.cdc.gov/eid/article/18/4/11-1627_article ER - End of Reference