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Volume 18, Number 6—June 2012
CME ACTIVITY - Research

Pretransplant Fecal Carriage of Extended-Spectrum β-Lactamase–producing Enterobacteriaceae and Infection after Liver Transplant, France

Frédéric BertComments to Author , Béatrice Larroque, Catherine Paugam-Burtz, Federica Dondero, François Durand, Estelle Marcon, Jacques Belghiti, Richard Moreau, and Marie-Hélène Nicolas-Chanoine
Author affiliations: Hôpital Beaujon, Clichy, France (F. Bert, B. Larroque, C. Paugam-Burtz, F. Dondero, F. Durand, E. Marcon, J. Belghiti, R. Moreau, M.H. Nicolas-Chanoine); Université Paris VII Faculté de Médecine D. Diderot, Paris, France (C. Paugam-Burtz, F. Durand, J. Belghiti, M.H. Nicolas-Chanoine); INSERM U 773 Centre de Recherche Biomédicale Bichat-Beaujon, CRB3, Paris (F. Durand, R. Moreau, M.H. Nicolas-Chanoine)

Main Article

Table 4

Comparison of patients with and without ESBLE infection, by univariate analysis, France, January 2001–April 2010*

Variable Patients with ESBLE infection, n = 39 Patients without ESBLE infection, n = 671 p value
Preoperative data
Mean age, y 49 50 0.55
Male sex 24 (61.5) 466 (69.4) 0.30
ESBLE fecal carriage 13 (33.3) 16 (2.4) <0.0001
Viral hepatitis 13 (33.3) 248 (37.1) 0.64
Hepatocellular carcinoma 7 (17.9) 214 (32.3) 0.061
Alcoholism 16 (41) 219 (32.6) 0.28
Acute liver failure 11 (28.2) 63 (9.4) 0.0011
HIV infection 1 (2.5) 20 (3) 1
MELD score >25 20 (51.3) 143 (21.4) <0.0001
Intensive care stay >48 h† 14 (35.9) 80 (11.2) <0.0001
Hospital stay >10 d† 20 (51.3) 185 (27.6) 0.0015
Spontaneous bacterial peritonitis† 7 (17.9) 63 (9.4) 0.082
Bacteremia† 5 (12.8) 70 (10.4) 0.59
Intraoperative data
Mean duration of surgery, min 488 509 0.12
Mean cold ischemia time, min 472 484 0.47
Kidney transplant 2 (5.1) 39 (5.8) 1
Living donor 3 (7.9) 56 (8.4) 1
Mean no. units red blood cells transfused 5.9 4.5 0.11
Roux-en-Y anastomosis 4 (10.2) 46 (7.6) 0.53
Postoperative data
Retransplantation 3 (7.7) 40 (6) 0.72
Return to surgery 23 (59) 228 (34) 0.0015
Acute renal failure 24 (66.7) 238 (38.1) 0.0007

*Values are no. (%) except as indicated. ESBLE, extended-spectrum β-lactamase–producing Enterobacteriaceae; MELD, Model for End-stage Liver Disease.
†In the 6 mo before liver transplant.

Main Article

Page created: May 17, 2012
Page updated: May 17, 2012
Page reviewed: May 17, 2012
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