TY - JOUR AU - Roy, Soumitra AU - Sandhu, Arbansjit AU - Medina, Angelica AU - Clawson, David AU - Wilson, James T1 - Adenoviruses in Fecal Samples from Asymptomatic Rhesus Macaques, United States T2 - Emerging Infectious Disease journal PY - 2012 VL - 18 IS - 7 SP - 1081 SN - 1080-6059 AB - Adenoviruses can cause infectious diarrheal disease or respiratory infections in humans; 2 recent reports have indicated probable human infection with simian adenoviruses (SAdVs). To assess the possibility of animal-to-human transmission of SAdVs, we tested fecal samples from asymptomatic rhesus macaques housed in 5 primate facilities in the United States and cultured 23 SAdV isolates. Of these, 9 were purified and completely sequenced; 3 SAdV samples from the American Type Culture Collection (SAdV-6, SAdV-18, and SAdV-20) were also completely sequenced. The sequence of SAdV-18 was closely related to that of human adenovirus F across the whole genome, and the new isolates were found to harbor 2 fiber genes similar to those of human adenovirus (HAdV) strains HAdV-40 and HAdV-41, which can cause infectious diarrhea. The high prevalence of adenoviruses in fecal samples from asymptomatic rhesus macaques and the similarity of the isolates to human strains indicates the possibility of animal-to-human transmission of SAdVs. KW - adenovirus KW - rhesus KW - macaque KW - fiber KW - hexon KW - DNA KW - polymerase KW - United States KW - feces KW - stool KW - fecal samples KW - viruses KW - asymptomatic KW - subclinical infection KW - macaques KW - PCR KW - monkeys DO - 10.3201/eid1807.111665 UR - https://wwwnc.cdc.gov/eid/article/18/7/11-1665_article ER - End of Reference