TY - JOUR AU - Wang, Guiqing AU - Huang, Tiangui AU - Surendraiah, Pavan Kumar Makam AU - Wang, Kemeng AU - Komal, Rashida AU - Zhuge, Jian AU - Chern, Chian-Ru AU - Kryszuk, Alexander AU - King, Cassidy AU - Wormser, Gary T1 - CTX-M β-Lactamase–producing Klebsiella pneumoniae in Suburban New York City, New York, USA T2 - Emerging Infectious Disease journal PY - 2013 VL - 19 IS - 11 SP - 1803 SN - 1080-6059 AB - CTX-M extended-spectrum β-lactamase (ESBL)–producing Klebsiella pneumoniae isolates are infrequently reported in the United States. In this study, we analyzed nonduplicate ESBL-producing K. pneumoniae and Escherichia coli clinical isolates collected during 2005–2012 at a tertiary care medical center in suburban New York City, USA, for the presence of blaCTX-M, blaSHV, blaTEM, and blaKPC genes. Despite a high prevalence of blaCTX-M genes in ESBL-producing E. coli since 2005, blaCTX-M genes were not detected in K. pneumoniae until 2009. The prevalence of CTX-M–producing K. pneumoniae increased significantly over time from 1.7% during 2005–2009 to 26.4% during 2010–2012 (p<0.0001). CTX-M-15 was the dominant CTX-M genotype. Pulsed-field gel electrophoresis and multilocus sequence typing revealed high genetic heterogeneities in CTX-M–producing K. pneumoniae isolates. This study demonstrates the recent emergence and polyclonal spread of multidrug resistant CTX-M–producing K. pneumoniae isolates among patients in a hospital setting in the United States. KW - Klebsiella pneumoniae KW - Escherichia coli KW - extended-spectrum beta-lactamases KW - beta-lactamases CTX-M-15 KW - pulsed-field gel electrophoresis KW - multilocus sequence typing KW - bacteria KW - antimicrobial resistance KW - New York KW - USA KW - United States DO - 10.3201/eid1911.121470 UR - https://wwwnc.cdc.gov/eid/article/19/11/12-1470_article ER - End of Reference