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Volume 19, Number 11—November 2013

Possible Association between Obesity and Clostridium difficile Infection

Jason Leung, Bob Burke, Dale Ford, Gail Garvin, Cathy Korn, Carol Sulis, and Nahid BhadeliaComments to Author 
Author affiliations: University of Michigan Hospital, Ann Arbor, Michigan, USA (Leung, J.); Boston Medical Center, Boston (B. Burke, D. Ford, G. Garvin, C. Korn, C. Sulis, N. Bhadelia)

Main Article

Table 1

Patient characteristics associated with cases of community onset, community-onset health care–associated, and health care onset cases of Clostridium difficile infections

CharacteristicCommunity onset n = 59 Community-onset health care–associated n = 32 Health care onset n = 41 p value
Demographic traits
Mean age [range]57.8 [22–96]63.7 [23–95]61.6 [21–96]0.31*
Male sex, no. (%)
27 (46)
10 (31)
23 (56)
Medication use, no. (%)
Prior antibiotic use31 (52.5)11 (34.4)33 (80)<0.001
Antiulcer medication
24 (41)
18 (56)
19 (46)
Physical status/illness, no. (%)
Obese (body mass index>30) 20 (34)4 (13)13 (32)0.078
Immunocompromised†14 (24)11 (34)11 (27)0.551
Diabetes14 (24)9 (28)7 (17)0.519
Irritable bowel disease
10 (17)
1 (3)
1 (2)
Required inpatient admission, no. (%)41 (69)29 (91)39 (95)0.002
Average days stayed7.78.218.6<0.001
Required intensive care unit stay11 (27)8 (28)24 (61)0.002

*P value for 1-way analysis of variance.
†Immunocomprised group included all malignancies, innate and acquired immune conditions such as HIV/AIDS, and congenital immune defects. This group excluded comorbidities listed separately.

Main Article

Page created: November 06, 2013
Page updated: November 06, 2013
Page reviewed: November 06, 2013
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