TY - JOUR AU - Drobeniuc, Jan AU - Greene-Montfort, Tracy AU - Le, Ngoc-Thao AU - Mixson-Hayden, Tonya AU - Ganova-Raeva, Lilia AU - Dong, Chen AU - Novak, Ryan AU - Sharapov, Umid AU - Tohme, Rania AU - Teshale, Eyasu AU - Kamili, Saleem AU - Teo, Chong-Gee T1 - Laboratory-based Surveillance for Hepatitis E Virus Infection, United States, 2005–2012 T2 - Emerging Infectious Disease journal PY - 2013 VL - 19 IS - 2 SP - 218 SN - 1080-6059 AB - To investigate characteristics of hepatitis E cases in the United States, we tested samples from persons seronegative for acute hepatitis A and B whose clinical specimens were referred to the Centers for Disease Control and Prevention during June 2005–March 2012 for hepatitis E virus (HEV) testing. We found that 26 (17%) of 154 persons tested had hepatitis E. Of these, 15 had not recently traveled abroad (nontravelers), and 11 had (travelers). Compared with travelers, nontravelers were older (median 61 vs. 32 years of age) and more likely to be anicteric (53% vs. 8%); the nontraveler group also had fewer persons of South Asian ethnicity (7% vs. 73%) and more solid-organ transplant recipients (47% vs. 0). HEV genotype 3 was characterized from 8 nontravelers and genotypes 1 or 4 from 4 travelers. Clinicians should consider HEV infection in the differential diagnosis of hepatitis, regardless of patient travel history. KW - jaundice KW - incidence KW - infectious disease transmission KW - travel KW - immunocompromised host KW - diagnostic techniques KW - hepatitis E KW - hepatitis E virus KW - HEV KW - Unites States KW - differential diagnosis KW - travel-related infections KW - surveillance KW - viruses KW - United States DO - 10.3201/eid1902.120961 UR - https://wwwnc.cdc.gov/eid/article/19/2/12-0961_article ER - End of Reference