Volume 19, Number 3—March 2013
CME ACTIVITY - Research
Increasing Pneumocystis Pneumonia, England, UK, 2000–2010
Table 2
Proportion of all Pneumocystis jirovecii–associated hospital admissions and change in population rates over time, England, UK, 2000–2010
Risk category* | No. admissions (% all cases) |
Annual rate/million population |
Rate ratio between periods (95% CI) | |||
---|---|---|---|---|---|---|
2000–2005 | 2006–2010 | 2000–2005 | 2006–2010 | |||
Any transplant† | 59 (6.3) | 193 (14.7) | 0.20 | 0.75 | 3.80 (2.84–5.09) | |
Other lung disease‡ | 120 (12.8) | 276 (21.0) | 0.24 | 0.47 | 1.97 (1.47–2.64) | |
Hematologic disorders | 217 (23.1) | 354 (26.9) | 0.32 | 0.81 | 2.55 (2.00–3.25) | |
Hematologic malignancy | 349 (37.1) | 568 (43.1) | 1.17 | 2.21 | 1.89 (1.66–2.16) | |
Connective tissue/inflammatory disease§ | 71 (7.6) | 120 (9.1) | 0.31 | 0.62 | 2.02 (1.56–2.61) | |
Renal failure and dialysis | 95 (10.1) | 208 (15.8) | 0.16 | 0.35 | 2.23 (1.56–3.17) | |
Immunosuppressive/ chemotherapeutic drugs | 47 (5.0) | 90 (6.8) | 0.73 | 1.38 | 1.90 (1.60–2.25) | |
Malignancy other than hematologic | 92 (9.8) | 160 (12.2) | 0.40 | 1.07 | 2.67 (2.16–3.31) | |
Not in the above risk categories | 255 (27.1) | 177 (13.4) | 0.85 | 0.69 | 0.81 (0.67–0.98) | |
Total no. cases¶ | 941 | 1,317 | 3.15 | 5.13 | 1.62 (1.50–1.77) |
*Excludes HIV infection.
†includes liver, heart, lung, kidney and bone transplants.
‡Includes tuberculosis, chronic obstructive pulmonary disease, cystic fibrosis, bronchiectasis, asthma, and interstitial lung disease.
§Includes systemic connective tissue disorder, psoriatic arthropathy, rheumatoid arthritis, and inflammatory bowel disease.
¶Because some patients belong to >1 risk category, numbers do not add up to the total number of cases.