TY - JOUR AU - Bruce, Michael AU - Zulz, Tammy AU - DeByle, Carolynn AU - Singleton, Ros AU - Hurlburt, Debby AU - Bruden, Dana AU - Rudolph, Karen AU - Hennessy, Thomas AU - Klejka, Joseph AU - Wenger, Jay T1 - Haemophilus influenzae Serotype a Invasive Disease, Alaska, USA, 1983–2011 T2 - Emerging Infectious Disease journal PY - 2013 VL - 19 IS - 6 SP - 932 SN - 1080-6059 AB - Before introduction of Haemophilus influenzae type b (Hib) vaccines, rates of Hib disease in Alaska’s indigenous people were among the highest in the world. Vaccination reduced rates dramatically; however, invasive H. influenzae type a (Hia) disease has emerged. Cases of invasive disease were identified through Alaska statewide surveillance during1983–2011. Of 866 isolates analyzed for serotype, 32 (4%) were Hia. No Hia disease was identified before 2002; 32 cases occurred during 2002–2011 (p<0.001). Median age of case-patients was 0.7 years; 3 infants died. Incidence of Hia infection (2002–2011) among children <5 years was 5.4/100,000; 27 cases occurred in Alaska Native children (18/100,000) versus 2 cases in non-Native children (0.5/100,000) (risk ratio = 36, p<0.001). From 12/2009 to 12/2011, 15 cases of Hia disease occurred in southwestern Alaska (in children <5 years, rate = 204/100,000). Since introduction of the Hib conjugate vaccine, Hia infection has become a major invasive bacterial disease in Alaska Native children. KW - Haemophilus influenzae KW - H. influenzae KW - serotype KW - Alaska KW - invasive disease KW - emerging pathogen KW - US KW - United States KW - bacteria KW - Hia KW - Hib KW - coccobacillus KW - Alaska Native people KW - pneumonia KW - bacteremia KW - meningitis KW - epiglottitis KW - septic arthritis KW - cellulitis KW - otitis media KW - pericarditis DO - 10.3201/eid1906.121805 UR - https://wwwnc.cdc.gov/eid/article/19/6/12-1805_article ER - End of Reference