Volume 19, Number 7—July 2013
Research
Mutation in Spike Protein Cleavage Site and Pathogenesis of Feline Coronavirus
Beth N. Licitra1, Jean K. Millet1, Andrew D. Regan, Brian S. Hamilton, Vera D. Rinaldi, Gerald E. Duhamel, and Gary R. Whittaker
Table 1
Status of cats sampled for feline coronavirus and mutations in spike protein cleavage site*
| FECV-infected cats | FIPV-infected cats | Total | |
|---|---|---|---|
| Cats harboring viruses with >1 mutated S1/S2 site | 2 | 10 | 12 |
| Cats harboring viruses with an intact S1/S2 site | 28 | 1 | 29 |
| Total | 30 | 11 | 41 |
FECV, feline enteric coronavirus; FIPV, feline infectious peritonitis; S1, receptor-binding domain of spike; S2, fusion domain of spike.
1These authors contributed equally to this article.
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