Volume 19, Number 8—August 2013
Dispatch
Recombinant Coxsackievirus A2 and Deaths of Children, Hong Kong, 2012
Cyril C.Y. Yip, Susanna K.P. Lau, Patrick C.Y. Woo, Samson S.Y. Wong, Thomas H.F. Tsang, Janice Y.C. Lo, Wai-Kwok Lam, Chak-Chi Tsang, Kwok-Hung Chan, and Kwok-Yung Yuen
Table
Pairwise sequence identities between coxsackievirus A2 strains from 4 children Hong Kong, China, 2012, in and other representative human enterovirus A strains
| Region | Nucleotide identity, % |
Amino acid identity, % |
|||
|---|---|---|---|---|---|
| CVA2F | Other human enterovirus A strains | CVA2F | Other human enterovirus A strains | ||
| 5′-UTR |
84.9–85.3 |
71.1–87.2 |
NA |
NA |
|
| Polyprotein |
79.3–79.4 |
69.1–78.4 |
96–96.1 |
76–88.4 |
|
| P1 | 81.6–81.7 | 64.8–69.1 | 96.9–97 | 67.4–74.6 | |
| VP4 | 80.2–80.7 | 61.8–70.8 | 97.1 | 63.8–81.2 | |
| VP2 | 81.6 | 66.1–70.3 | 97.6 | 72.9–79.2 | |
| VP3 | 82.4–82.6 | 66.1–72.8 | 97.1–97.5 | 70.7–83.3 | |
| VP1 |
81.1–81.2 |
60.1–65.9 |
95.9–96.3 |
56.7–67.3 |
|
| P2 | 78–78.2 | 70.5–83.8 | 96.9–97.1 | 78.9–98.4 | |
| 2A | 78–78.2 | 65.3–82 | 96 | 69.3–98.7 | |
| 2B | 73.7–74.1 | 66–84.2 | 94.9 | 76.8–99 | |
| 2C |
79.2–79.4 |
71.9–86.3 |
97.9–98.2 |
83–98.8 |
|
| P3 | 77.8–77.9 | 72–87.8 | 94.4–94.6 | 81.1–97.9 | |
| 3A | 79.8–80.6 | 69–86.4 | 94.2–95.3 | 68.6–98.8 | |
| 3B | 74.2 | 62.1–93.9 | 90.9 | 68.2–95.5 | |
| 3C | 77.4 | 72.3–87.4 | 95.1 | 84.2–98.9 | |
| 3D |
77.7–77.9 |
72.2–89.6 |
94.2–94.4 |
82.7–98.5 |
|
| 3′-UTR | 83.3–84.5 | 38.9–96.3 | NA | NA | |
*CVA2F, coxsackievirus A prototype strain Fleetwood; UTR, untranslated region; NA, not applicable; P1, capsid protein 1; VP, viral protein; P2, nonstructural protein 2; P3, nonstructural protein 3.
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Page updated: July 19, 2013
Page reviewed: July 19, 2013
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