Volume 2, Number 2—April 1996
An Outbreak of Ross River Virus Disease in Southwestern Australia
More than 540 serologically confirmed cases of Ross River (RR) virus disease have been reported from the southwest region of Western Australia since November 1995 (Figure 1). Most affected by the mosquito-borne disease are communities on the Swan Coastal Plain south of Perth. Cases have also been reported from towns farther south or inland and from Perth itself. These regions were foci of RR virus activity during previous southwest outbreaks in 1988–89 and 1991–92 (1,2); however, the current outbreak differs somewhat in the timing and location of virus activity. This article is a preliminary overview of the incidence of disease, mosquito and virus activity, and environmental conditions before and during the outbreak.
Monitoring of the incidence of human disease provided no indication of abnormally high levels of RR virus activity until mid-December 1995 when the number of reported cases began to rise sharply. In contrast, monitoring of mosquito breeding sites, adult mosquito populations, and environmental conditions in late October and November 1995 showed a potential for high levels of virus transmission.
The areas affected most, in terms of numbers of cases and attack rates (not shown), are coastal towns and communities around the Leschenault Inlet (including the city of Bunbury), between 165 and 190 km south of Perth and in the shires of Capel and Busselton, as well as on the coast between 190 and 245 km south of Perth (Table 1). These regions are popular tourist destinations during the summer holidays. It appears that many holiday-makers from elsewhere in the southwest, as well as local residents, were exposed to infected mosquitoes in these regions during the Christmas–New Year period.
Many of the Perth cases are from semirural, outlying suburbs, but some are from suburbs closer to the city center, often near the Swan and Canning rivers or fresh water wetlands and lakes. Follow-up questionnaires indicate that a considerable proportion of metropolitan cases were in persons exposed in the southwest, particularly in the Leschenault, Capel, and Busselton regions. However, many cases from Perth also appear to have been locally acquired. Locally acquired cases were also present during the two previously reported outbreaks.
Many cases have also been reported from the Peel region, 70 km to 130 km south of Perth, surrounding the Peel Inlet and Harvey Estuary. However, considerably more cases had been reported by late February in the Peel region during the 1988–89 and 1991–92 outbreaks. Also, during 1988 and 1991 virus activity in the Peel outbreaks commenced earlier than in the Leschenault and Capel-Busselton regions; this is apparently not the case during the current outbreak (Table 1). The reasons for these differences are not yet clear, but extensive control of saltmarsh mosquito breeding has been carried out in the Peel region this season.
Large saltmarshes and brackish wetlands in the Peel, Leschenault, Capel, and Busselton regions provide an ideal breeding habitat for Ae. camptorhynchus mosquitoes (5). This species is the major vector of RR virus in the southwest of Western Australia. Surveillance during previous outbreaks has clearly shown that the risk for RR virus transmission in coastal regions of the southwest increases markedly if large populations of adult Ae. camptorhynchus persist into late spring and summer (1,2). Adult mosquito populations and RR virus activity are monitored routinely by our laboratory at up to 40 sites between Rockingham and Dunsborough (50 km to 260 km south of Perth) each fortnight through spring and summer. In addition, saltmarshmosquito breeding sites are regularly monitored by local authorities and the health department.
Widespread breeding of Ae. camptorhynchus (larvae) was observed in the Capel–Busselton region in late October 1995 and prompted a health department warning of an increased risk for RR virus transmission in the southwest. However, almost no activities to control mosquito larvae were carried out in the worst-affected regions. The adult mosquito monitoring program subsequently showed that extremely large populations of Ae. camptorhynchus survived through November and December. (Figure 2 and Figure 3). The number of mosquitoes collected per trap per night in the Capel–Busselton region during November and December 1995 (up to 10,000 mosquitoes per trap at some sites) is unprecedented in the 5 years of surveillance in the region. Similar results were obtained in the Leschenault region where the number of Ae. camptorhynchus mosquitoes collected during December 1995 and January 1996 were similar to those observed during the 1991–92 outbreak. These observations, along with the expected seasonal exodus of city dwellers to these areas during the Christmas holidays, prompted a second warning by the health department in December 1995.
Fourteen isolates of RR virus were obtained from Ae. camptorhynchus mosquitoes collected at a major wetland west of Busselton on December 7, 1995 (Figure 3). Large populations of potential vertebrate hosts (western gray kangaroos, Macropus fuliginosus) were also observed in close proximity to this site throughout the spring and summer. Case follow-up questionnaires indicate thata large percentage of Busselton patients were exposed in this locality. The last time RR virus was isolated from this site was during the 1991-92 outbreak in the region.
Mosquito populations in the Capel–Busselton region (Figure 3) and most areas of the Leschenault region dropped rapidly by mid-January 1996. However, further cases with dates of onset in February have been reported (Table 1), which suggests a high infection rate in the remaining adults. The results of processing of adult mosquitoes collected in February are, therefore, eagerly awaited.
Several isolates of RR virus were also obtained from mosquitoes collected in the Peel region (Table 2). The recent isolations from Ae. vigilax are of particular concern. This species is regarded as the major vector of RR virus in coastal areas of northern and eastern Australia (3,4), but until now it has had little or no role in transmitting RR virus in the southwest (1,2). Ae. vigilax has become the dominant species in the Peel region between December and March since the opening of the Dawesville Channel. This mosquito is a vicious biter, even during the day if weather conditions are suitable, and is known to disperse considerable distances from breeding sites. Thus, the potential for interaction between infected mosquitoes and humans in the Peel region may be greater and occur over a wider area than originally thought.
Analyses of environmental conditions before and during the outbreak are not yet complete. However, record-high daily rainfall was recorded in October at numerous centers in the southwest. Above-average rainfall occurred in November in Perth and Mandurah and in December in Mandurah, Banbury, and Capel–Busselton. These were accompanied by above-average October and November temperatures at many southwest centers. A series of extremely high tides was also recorded along the Peel–Leschenault region coast around December 20. This resulted from unusually early cyclonic activity (three cyclones) along the north and west coasts of Western Australia during December. Clearly, a combination of some or all of these factorsenabled widespread breeding and survival of vector mosquito species. Late spring and summer rains, a short-term rise in sea level (accompanied by higher tides), and mild spring and summer temperatures were predisposing factors during previous outbreaks in the southwest (2,4).
Preliminary analysis of the location of virus activity (measured as either human cases or isolations from mosquitoes) shows that activity is far less likely in regions in which virus activity was detected in the previous season. Thus, length of time since the previous outbreak also appears to be a predisposing factor for higher levels of virus activity in the southwest. The reason for this is not yet known but may be due to higher levels of immunity in recently infected populations of enzootic or amplifying vertebrate hosts. This may help explain the comparatively reduced numbers of cases in the Peel region this season following moderate levels of virus activity last year, which coincided with the opening of the Dawesville Channel.
A small number of cases of Barmah Forest virus infection have been diagnosed during the current outbreak. Numerous cases of a RR virus-like disease have also been reported, as in the 1988-89 and 1991-92 outbreaks. Serum from these patients has been tested for IgM antibody to RR and Barmah Forest viruses but is negative for both viruses. Some of these cases may be in persons that had not seroconverted at the time of the first blood sample. However, many have since provided further samples, all of which have had negative test results. Sera from these patients are being tested against a wide range of other Australian arboviruses, and more blood samples will be sought to ensure that the phenomenon is not due to an extremely delayed immunologic response to RR virus.
- Lindsay MD, Condon R, Mackenzie JS, Johansen C, D’Ercole M, Smith D. A major outbreak of Ross River virus infection in the south-west of Western Australia and the Perth metropolitan area. Commun Dis Intell. 1992;16:290–4.
- Lindsay MD, Latchford JA, Wright AE, Mackenzie JS. Studies on the ecology of Ross River virus in the southwest of Western Australia. Arbovirus Research in Australia. 1989;5:28–32.
- Mackenzie JS, Lindsay MD, Coelen RJ, Broom AK, Hall RA, Smith DW. Arch Virol 1994:136:447-67. Russell RC. Ross River virus: disease trends and vector ecology in Australia. BullSoc Vector Ecol. 1994;19:73–81.Arboviruses causing human disease in the Australasian zoogeographic region
- Wright AE. Report on the mosquito eradication campaign: survey of mosquitoes in the Bunbury region, Western Australia. Health Department of Western Australia, 1988.
- Wright AE. Report on the mosquito eradication campaign: survey of mosquitoes in the Mandurah region, Western Australia. Health Department of Western Australia, 1988.
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Table of Contents – Volume 2, Number 2—April 1996
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