TY - JOUR AU - Freiesleben de Blasio, Birgitte AU - Flem, Elmira AU - Latipov, Renat AU - Kuatbaeva, Ajnagul AU - Kristiansen, Ivar Sønbø T1 - Dynamic Modeling of Cost-effectiveness of Rotavirus Vaccination, Kazakhstan T2 - Emerging Infectious Disease journal PY - 2014 VL - 20 IS - 1 SP - 29 SN - 1080-6059 AB - The government of Kazakhstan, a middle-income country in Central Asia, is considering the introduction of rotavirus vaccination into its national immunization program. We performed a cost-effectiveness analysis of rotavirus vaccination spanning 20 years by using a synthesis of dynamic transmission models accounting for herd protection. We found that a vaccination program with 90% coverage would prevent ≈880 rotavirus deaths and save an average of 54,784 life-years for children <5 years of age. Indirect protection accounted for 40% and 60% reduction in severe and mild rotavirus gastroenteritis, respectively. Cost per life year gained was US $18,044 from a societal perspective and US $23,892 from a health care perspective. Comparing the 2 key parameters of cost-effectiveness, mortality rates and vaccine cost at <US $2.78 per dose, vaccination program costs would be entirely offset. To further evaluate efficacy of a vaccine program, benefits of indirect protection conferred by vaccination warrant further study. KW - viruses KW - rotavirus KW - vaccination KW - cost-effectiveness KW - dynamic modeling KW - herd immunity KW - break-even price KW - vaccine KW - Kazakhstan DO - 10.3201/eid2001.130019 UR - https://wwwnc.cdc.gov/eid/article/20/1/13-0019_article ER - End of Reference