Progenitor “Mycobacterium canettii” Clone Responsible for Lymph Node Tuberculosis Epidemic, Djibouti
Yann Blouin, Géraldine Cazajous, Céline Dehan, Charles Soler, Rithy Vong, Mohamed Osman Hassan, Yolande Hauck, Christian Boulais, Dina Andriamanantena, Christophe Martinaud, Émilie Martin, Christine Pourcel, and Gilles Vergnaud
Author affiliations: Université Paris-Sud, Orsay, France (Y. Blouin, Y. Hauck, C. Pourcel, G. Vergnaud); Centre National de la Recherche Scientifique, Orsay (Y. Blouin, Y. Hauck, C. Pourcel, G. Vergnaud); Hôpital Militaire Bouffard, Djibouti, Republic of Djibouti (G. Cazajous, C. Dehan, C. Boulais); Hôpital d'Instruction des Armées Percy, Clamart, France (C. Soler, R. Vong, C. Martinaud); Hôpital Paul Faure, Djibouti (M. Osman Hassan); Hôpital d'Instruction des Armées Bégin, Saint-Mandé, France (D. Andriamanantena); Centre Hospitalier Lyon Sud, Lyon, France (E. Martin); Institut de Recherche Biomédicale des Armées, Brétigny, France (G. Vergnaud)
Figure 1. . Starburst genealogy within clone A of Mycobacterium canettii isolates, Djibouti, 2010–2013. The size of each branch, corresponding to the number of polymorphisms between 2 nodes, is indicated. The tree is based upon 55 polymorphisms, 18 of which are clustered in 1,660 base pairs. The relative position of Percy1129 is shown with (blue) or without (red) these 18 polymorphisms. The isolation year is indicated near each strain. The position of a hypothetical ancestor is indicated by the red. All cluster A strains are 2 up to a maximum of 5 polymorphisms away from this hypothetical ancestor after removal of the exceptional polymorphism cluster found in strain Percy1129. SNP, single-nucleotide polymorphism.
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