Volume 20, Number 11—November 2014
Research
Drug-Resistant Candida glabrata Infection in Cancer Patients
Dimitrios Farmakiotis1, Jeffrey J. Tarrand, and Dimitrios P. Kontoyiannis
Table 2
Factors present at the time of candidemia and associated with fluconazole resistance, in cancer patients with Candida glabrata fungemia, MD Anderson Cancer Center, Houston, Texas, USA, March 2005–September 2013*
| Factor | No. (%) cases |
Multivariate analysis |
||||
|---|---|---|---|---|---|---|
| Dose-dependent, n = 116 | Resistant, n = 30 | p value | Odds ratio (95% CI) | p value | ||
| Hematologic malignancy | 27 (23.27) | 20 (66.66) | <0.001 | 3.63 (1.18–11.17) | 0.024 | |
| Leukemia | 12 (10.34) | 10 (33.33) | <0.001 | |||
| HSCT | 6 (5.17) | 10 (33.33) | <0.001 | |||
| Monocytopenia, <100 cells/μL | 26 (22.41) | 13 (43.33) | 0.021 | |||
| Any corticosteroids† | 60 (51.72) | 25 (83.33) | 0.002 | |||
| Intensive care unit stay | 42 (36.21) | 17 (56.66) | 0.042 | |||
| Mechanical ventilation | 17 (14.66) | 10 (33.33) | 0.019 | 3.96 (1.16–13.51) | 0.028 | |
| Presence of a central line | 101 (87.06) | 30 (100) | 0.047 | |||
| Azole exposure† | 24 (20.68) | 20 (66.66) | 0.001 | 5.09 (1.66–15.64) | 0.004 | |
| Echinocandin exposure† | 17 (14.65) | 15 (50) | <0.001 | |||
| Echinocandin resistance | 6 (5.17) | 9 (30) | <0.001 | 5.23 (1.31–20.78) | 0.019 | |
*Blank cells indicate that the respective variables did not contribute significantly and were not retained in the final multivariate model (p>0.1). HSCT, hematopoietic stem cell transplantation.
†Within 1 month before the day of candidemia (day of blood collection for culture).
1Current affiliation: Harvard Medical School Brigham and Women’s Hospital and Dana Farber Cancer Institute, Boston, Massachusetts, USA
Page created: October 15, 2014
Page updated: October 15, 2014
Page reviewed: October 15, 2014
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