Bacterial Pathogens Associated with Hidradenitis Suppurativa, France
, Hélène Coignard-Biehler, Jean-Philippe Jais, Gilles Quesne, Eric Frapy, Sylvain Poirée, Anne-Sophie Le Guern, Anne Le Flèche-Matéos, Alain Hovnanian, Paul-Henry Consigny, Olivier Lortholary, Xavier Nassif, Aude Nassif, and Olivier Join-Lambert
Author affiliations: Université Paris Descartes, Sorbonne Paris Cité, Paris, France (H. Guet-Revillet, J.-P. Jais, E. Frapy, A. Hovnanian, O. Lortholary, X. Nassif, O. Join-Lambert); Assistance-Publique Hôpitaux de Paris, Paris (H. Guet-Revillet, H. Coignard-Biehler, J-P. Jais, G. Quesne, S. Poirée, O. Lortholary, X. Nassif, O. Join-Lambert); Institut National de la Santé et de la Recherche U1151 eq11, Paris (H. Guet-Revillet, E. Frapy, X. Nassif, O. Join-Lambert); Institut National de la Santé et de la Recherche U872 eq22 (J-P. Jais); Institut National de la Santé et de la Recherche U 781, Paris (A. Hovnanian); Institut Pasteur, Paris (A. Le Flèche-Matéos, A-S. Le Guern, P.-H. Consigny, A. Nassif)
Figure. Microbial diversity of hidradenitis suppurativa (HS) lesions as assessed by high-throughput 454 sequencing. The bacterial diversity of 6 consecutive and representative HS lesions was assessed by high-throughput sequencing. Sample 1 corresponded to an acute Staphylococcus lugdunensis abscess sampled by needle aspiration. Samples 2–3 (swabs) corresponded to Hurley stage 2 lesions of the axilla and inguinal folds, respectively. Samples 4–6 (swabs) corresponded to Hurley stage 3 lesions of the inguinal, axilla and gluteal fold, respectively. Staphylococcus spp. represented >99% of sequences of sample 1, whereas Prevotella spp. represented the most abundant taxon in 4/5 of these chronic suppurative lesions.
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