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Volume 20, Number 3—March 2014
Research

High-level Relatedness among Mycobacterium abscessus subsp. massiliense Strains from Widely Separated Outbreaks

Hervé Tettelin, Rebecca M. Davidson, Sonia Agrawal, Moira L. Aitken, Shamira Shallom, Nabeeh A. Hasan, Michael Strong, Vinicius Calado Nogueira de Moura, Mary Ann De Groote, Rafael S. Duarte, Erin Hine, Sushma Parankush, Qi Su, Sean C. Daugherty, Claire M. Fraser, Barbara A. Brown-Elliott, Richard J. Wallace, Steven M. Holland, Elizabeth P. Sampaio, Kenneth N. Olivier, Mary Jackson, and Adrian M. ZelaznyComments to Author 
Author affiliations: University of Maryland School of Medicine, Baltimore, Maryland, USA (H. Tettelin, S. Agrawal, E. Hine, S. Parankush, Q. Su, S.C. Daugherty, C.M. Fraser); National Jewish Health, Denver, Colorado, USA (R.M. Davidson, N.A. Hasan, M. Strong); University of Washington, Seattle, Washington, USA (M.L. Aitken); National Institutes of Health, Bethesda, Maryland, USA (S. Shallom, S.M. Holland, E.P. Sampaio, K.N. Olivier, A.M. Zelazny); University of Colorado Denver, Aurora, Colorado, USA (N.A. Hasan, M. Strong); Colorado State University, Fort Collins, Colorado, USA (V. Calado Nogueira de Moura, M.A. De Groote, M. Jackson); Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil (R.S. Duarte); University of Texas Health Northeast, Tyler, Texas, USA (B.A. Brown-Elliott, R.J. Wallace Jr.)

Main Article

Table 2

Detection of rpoB and secA1 SNP signature in the Mycobacterium abscessus group and rapidly growing mycobacteria*

Strains No. strains with SNP/no. tested (%)
rpoB T 2569 rpoB C 2760 rpoB T 2569 and rpoB C 2760 secA1 T 820
MAB (CSU) 0/44 (0) 44/44 (100) 0/44 (0) NT
MAB (NIH) 0/29 (0) 29/29 (100) 0/29 (0) 0/29 (0)
MMA non-outbreak strain (CSU) 1/14 (7) 1/14 (7) 0/14 (0) NT
MMA non- outbreak strain (NIH) 4/12 (33) 10/ 12 (83) 4/12 (33) 2/12 (17)
MMA Seattle 4/ 4 (100) 4/4 (100) 4/4 (100) 3/3 (100)
MMA Brazil 9/ 9 (100) 9/9 (100) 9/9 (100) NT
MBO (CSU) 0/11 (0) 11/11 (100) 0/11 (0) NT
MBO (NIH) 0/2 (0) 2/2 (100) 0/2 (0) 0/2 (0)
Other RGM (CSU) 0/42 (0) 0/42 (0) 0/42 (0) NT
MMA type strain 0/1 (0) 0/1 (0) 0/1 (0) 0/1 (0)
MMA In silico data†
MMA UK 6/6 (100) 6/6 (100) 6/6 (100) 6/6 (100)
MMA Seattle 3/3 (100) 3/3 (100) 3/3 (100) 3/3 (100)
MMA Brazil 2/2 (100) 2/2 (100) 2/2 (100) 0/2 (0)
47J26 1/1 (100) 1/ 1 (100) 1/1 (100) 1/1 (100)
M18 1/1 (100) 1/1 (100) 1/1 (100) 1/1 (100)
1S-151–0930 1/1 (100) 1/1 (100) 1/1 (100) 0/1 (0)
5S-0817 0/1 (0) 1/1 (100) 0/1 (0) 0/1 (0)
M115 0/1 (0) 0/1 (0) 0/1 (0) 0/1 (0)
M139 0/1 (0) 1/1 (100) 0/1 (0) 0/1 (0)
M148 0/1 (0) 0/1 (0) 0/1 (0) 0/1 (0)
M154 0/1 (0) 0/1 (0) 0/1 (0) 0/1 (0)
M156 0/1 (0) 0/1 (0) 0/1 (0) 0/1 (0)
M159 0/1 (0) 0/1 (0) 0/1 (0) 0/1 (0)
M172 0/1 (0) 0/1 (0) 0/1 (0) 0/1 (0)
Asan 50594 0/1 (0) 1/1 (100) 0/1 (0) 0/1 (0)

*SNP, single-nucleotide polymorphism; MAB, M. abscessus subsp. abscessus; NT, not tested. CSU, Colorado State University; NIH, National Institutes of Health; MMA, M. abscessus subsp. massiliense; MBO, M. abscessus subsp. bolletii; RGM, rapidly growing mycobacteria.
†Information collected from available whole genome sequencing data.

Main Article

Page created: February 19, 2014
Page updated: February 19, 2014
Page reviewed: February 19, 2014
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