TY - JOUR AU - Agoti, Charles AU - Otieno, James AU - Gitahi, Caroline AU - Cane, Patricia AU - Nokes, D. James T1 - Rapid Spread and Diversification of Respiratory Syncytial Virus Genotype ON1, Kenya T2 - Emerging Infectious Disease journal PY - 2014 VL - 20 IS - 6 SP - 950 SN - 1080-6059 AB - Respiratory syncytial virus genotype ON1, which is characterized by a 72-nt duplication in the attachment protein gene, has been detected in >10 countries since first identified in Ontario, Canada, in 2010. We describe 2 waves of genotype ON1 infections among children admitted to a rural hospital in Kenya during 2012. Phylogenetic analysis of attachment protein gene sequences showed multiple introductions of genotype ON1; variants distinct from the original Canadian viruses predominated in both infection waves. The genotype ON1 dominated over the other group A genotypes during the second wave, and some first wave ON1 variants reappeared in the second wave. An analysis of global genotype ON1 sequences determined that this genotype has become considerably diversified and has acquired signature coding mutations within immunogenic regions, and its most recent common ancestor dates to ≈2008–2009. Surveillance of genotype ON1 contributes to an understanding of the mechanisms of rapid emergence of respiratory viruses. KW - attachment protein KW - G glycoprotein KW - G protein gene KW - phylogenetic analysis KW - ON1 KW - genotype ON1 KW - respiratory syncytial virus KW - RSV KW - viruses KW - respiratory viruses KW - pneumonia KW - epidemics KW - humans KW - surveillance KW - Kenya DO - 10.3201/eid2006.131438 UR - https://wwwnc.cdc.gov/eid/article/20/6/13-1438_article ER - End of Reference