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Volume 20, Number 6—June 2014
Dispatch

Sequential Gastroenteritis Episodes Caused by 2 Norovirus Genotypes

Gabriel I. ParraComments to Author  and Kim Y. GreenComments to Author 
Author affiliations: National Institutes of Health, Bethesda, Maryland, USA

Main Article

Figure 1

Characterization of norovirus detected in stool samples and levels of local IgA responses for each infection. A) Phylogenetic tree of the major capsid protein (VP1) region from representative norovirus strains from each of the 22 genotypes within strain GII. Representative strains from each GII.4 and GII.6 cluster were compared with the strains reported in this article (boxed). For each strain, the name/year/country of isolation are shown. B) Levels of IgA in feces collected during the first and

Figure 1. Characterization of norovirus detected in stool samples and levels of local IgA responses for each infectionA) Phylogenetic tree of the major capsid protein (VP1) region from representative norovirus strains from each of the 22 genotypes within strain GIIRepresentative strains from each GII.4 and GII.6 cluster were compared with the strains reported in this article (boxed)For each strain, the name/year/country of isolation are shownB) Levels of IgA in feces collected during the first (G11.4) and (G11.6) second infectionsELISA plates were coated with 1 μg/mL of each virus-like particle (VLP)Fecal samples were collected daily (D) and weekly (W), diluted to 1:500 in phosphate-buffered saline (pH 7.4), and tested for the presence of IgA with a polyclonal anti-human IgA conjugateThe experiment was performed twice in duplicate wellsBars represent mean; error bars represent the standard errors of the meanOD, optical density.

Main Article

Page created: May 16, 2014
Page updated: May 16, 2014
Page reviewed: May 16, 2014
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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