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Volume 20, Number 7—July 2014
Research

Changes in Capsule and Drug Resistance of Pneumococci after Introduction of PCV7, Japan, 2010–2013

Naoko Chiba, Miyuki Morozumi, Michi Shouji, Takeaki Wajima, Satoshi Iwata, Kimiko UbukataComments to Author , and the Invasive Pneumococcal Diseases Surveillance Study Group
Author affiliations: Keio University School of Medicine, Tokyo, Japan (N. Chiba, M. Morozumi, S. Iwata, K. Ubukata); Kitasato University, Tokyo (N. Chiba, M. Morozumi, K. Ubukata); National Cancer Center Hospital, Tokyo (M. Shouji); Tokyo University of Pharmacy and Life Sciences, Tokyo (T. Wajima)

Main Article

Table 2

Year-to-year changes in prevalence of vaccine and nonvaccine serotypes of Streptococcus pneumoniae in children after introduction of PCV7, Japan, April 2010–March 2013*

Disease and serotype Isolates, no. (%)
p value
2010, 
n = 300† 2011, 
n = 146‡ 2012, 
n = 156§
Meningitis 0.006
VT 42 (14.0) 17 (11.6) 6 (3.8)
  NVT
20 (6.7)
17 (11.6)
15 (9.6)

Sepsis and bacteremia <0.001
VT 111 (37.0) 42 (28.8) 13 (8.3)
  NVT
48 (16.0)
39 (26.7)
94 (60.3)

Pneumonia <0.001
VT 54 (18.0) 14 (9.6) 3 (1.9)
  NVT
8 (2.7)
6 (4.1)
21 (13.5)

Other 0.147
VT 13 (4.3) 7 (4.8) 1 (0.6)
  NVT
4 (1.3)
4 (2.7)
3 (1.9)

Total <0.001
  VT 220 (73.3) 80 (54.8) 23 (14.7)
  NVT 80 (26.7) 66 (45.2) 133 (85.3)

*PCV7, 7-valent pneumoccal conjugate vaccine; VT, vaccine serotype (serotypes 4, 6B, 9V, 14, 18C, 19F, 23F); NVT, serotypes not included
in PCV7.
†Voluntary vaccination with PCV7.
‡Implementation of Urgent Promotion of Vaccination incentive.
§Just before the introduction of 13-valent PCV.

Main Article

Page created: June 17, 2014
Page updated: June 17, 2014
Page reviewed: June 17, 2014
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