TY - JOUR AU - Deng, Xiangyu AU - Desai, Prerak AU - den Bakker, Henk AU - Mikoleit, Matthew AU - Tolar, Beth AU - Trees, Eija AU - Hendriksen, Rene AU - Frye, Jonathan AU - Porwollik, Steffen AU - Weimer, Bart AU - Wiedmann, Martin AU - Weinstock, George AU - Fields, Patricia AU - McClelland, Michael T1 - Genomic Epidemiology of Salmonella enterica Serotype Enteritidis based on Population Structure of Prevalent Lineages T2 - Emerging Infectious Disease journal PY - 2014 VL - 20 IS - 9 SP - 1481 SN - 1080-6059 AB - Salmonella enterica serotype Enteritidis is one of the most commonly reported causes of human salmonellosis. Its low genetic diversity, measured by fingerprinting methods, has made subtyping a challenge. We used whole-genome sequencing to characterize 125 S. enterica Enteritidis and 3 S. enterica serotype Nitra strains. Single-nucleotide polymorphisms were filtered to identify 4,887 reliable loci that distinguished all isolates from each other. Our whole-genome single-nucleotide polymorphism typing approach was robust for S. enterica Enteritidis subtyping with combined data for different strains from 2 different sequencing platforms. Five major genetic lineages were recognized, which revealed possible patterns of geographic and epidemiologic distribution. Analyses on the population dynamics and evolutionary history estimated that major lineages emerged during the 17th–18th centuries and diversified during the 1920s and 1950s. KW - Salmonella enterica serotype Enteritidis KW - genome sequencing KW - SNP KW - genomic epidemiology KW - subtyping, evolution, bacteria KW - subtyping KW - evolution KW - bacteria DO - 10.3201/eid2009.131095 UR - https://wwwnc.cdc.gov/eid/article/20/9/13-1095_article ER - End of Reference