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Volume 21, Number 1—January 2015

Clinical Course and Long-Term Outcome of Hantavirus-Associated Nephropathia Epidemica, Germany

Joerg Latus, Matthias Schwab, Evelina Tacconelli, Friedrich-Michael Pieper, Daniel Wegener, Juergen Dippon, Simon Müller, David Zakim, Stephan Segerer, Daniel Kitterer, Martin Priwitzer, Barbara Mezger, Birgit Walter-Frank, Angela Corea, Albrecht Wiedenmann, Stefan Brockmann, Christoph Pöhlmann, M. Dominik Alscher, and Niko BraunComments to Author 
Author affiliations: Robert-Bosch-Hospital, Stuttgart, Germany (J. Latus, F.-M. Pieper, D. Wegener, D. Zakim, D. Kitterer, C. Pöhlmann, M.D. Alscher, N. Braun); Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart (M. Schwab); University Hospital Tübingen, Germany (M. Schwab, E. Tacconelli); University of Stuttgart, Stuttgart (J. Dippon, S. Müller); University Hospital Zurich, Zurich, Switzerland (S. Segerer); Local Health Authority, Stuttgart (M. Priwitzer, B. Mezger); Local Health Authority, Böblingen, Germany (B. Walter-Frank); Local Health Authority, Esslingen, Germany (A. Corea, A. Wiedenmann); Local Health Authority, Reutlingen, Germany (S. Brockmann)

Main Article

Table 1

Baseline characteristics for 456 persons during acute hantavirus infection, Germany, 2001–2012

Variable Median value (range) or no. or % patients positive for variable
Sex, no.
M 290
Age at diagnosis
48 y (40–59)
Patient status, no.
Inpatient 335
Duration of hospital stay
7 d (5–9)
Duration of illness at hospital admission or first visit to general practitioner/nephrologist
5 d (3–7)
Duration of fever before hospital admission
4 d (2–6)
Duration of disease
4 wk (2–8)
Assumed exposure to virus, %
Occupational 7
During leisure activities
Symptoms, %
Abdominal 33
Back 67
Limbs 71
Headache 68
Visual disorders 22
Diarrhea 20
Nausea/vomiting 47
Dyspnea 2
Loss of appetite 4
Fatigue 7
Clinical signs
Fever, % 90
Duration of fever 5 d (3–7)
Hemorrhage, % 7
Blood pressure
Systolic, 130 mm Hg (120–146)
Diastolic 80 mm Hg (71–90)
Heart rate 76 beats/min (64–86)
Hypertension, % 15
Hypotension, % 10
Shock, % 1
Chest radiograph, % 47
Pathologic findings on radiograph, % 23
Abdominal ultrasound, % 65
Splenomegaly, % 14
Hepatomegaly, % 4
Acute kidney injury, %* 86

*According to RIFLE (risk of renal dysfunction) criteria (27).

Main Article

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