TY - JOUR AU - Langereis, Jeroen AU - de Jonge, Marien T1 - Invasive Disease Caused by Nontypeable Haemophilus influenzae T2 - Emerging Infectious Disease journal PY - 2015 VL - 21 IS - 10 SP - 1711 SN - 1080-6059 AB - The incidence of severe Haemophilus influenza infections, such as sepsis and meningitis, has declined substantially since the introduction of the H. influenzae serotype b vaccine. However, the H. influenzae type b vaccine fails to protect against nontypeable H. influenzae strains, which have become increasingly frequent causes of invasive disease, especially among children and the elderly. We summarize recent literature supporting the emergence of invasive nontypeable H. influenzae and describe mechanisms that may explain its increasing prevalence over the past 2 decades. KW - Haemophilus influenzae KW - sepsis KW - meningitis KW - humoral immunity KW - cellular immunity KW - virulence KW - pathogenicity KW - vaccines KW - bacteria KW - invasive disease KW - pneumonia KW - nontypeable DO - 10.3201/eid2110.150004 UR - https://wwwnc.cdc.gov/eid/article/21/10/15-0004_article ER - End of Reference