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Volume 21, Number 11—November 2015

Carbapenem-Resistant Enterobacteriaceae in Children, United States, 1999–2012

Latania K. LoganComments to Author , John P. Renschler, Sumanth Gandra, Robert A. Weinstein, Ramanan Laxminarayan, and for the Centers for Disease Control and Prevention Epicenters Program
Author affiliations: Rush University Medical Center, Chicago, Illinois, USA (L.K. Logan, R.A. Weinstein); John H. Stroger, Jr. Hospital of Cook County, Chicago (L.K. Logan, R.A. Weinstein); Center for Disease Dynamics, Economics and Policy, Washington, DC, USA (J.P. Renschler, S. Gandra, R. Laxminarayan); Public Health Foundation of India, New Delhi, India (R. Laxminarayan); Princeton University, Princeton, New Jersey, USA (R. Laxminarayan)

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Table 2

Inpatient and outpatient CRE counts by species Enterobacteriaceae, The Surveillance Network–USA database, 1999–2012*

No. (%) isolates analyzed, n = 245,257 No. (%) CRE isolates analyzed, n = 89 No. (%) isolates analyzed, n = 63,880 No. (%) CRE isolates analyzed, n = 171
Escherichia coli 197,807 (80.65) 27 (29.35) 36,139 (56.57) 31 (18.13)
Proteus mirabilis 15,738 (6.42) 2 (2.17) 8,747 (13.69) 56 (32.75)
Klebsiella pneumoniae 14,115 (5.76) 22 (23.91) 8,620 (13.49) 70 (40.94)
Enterobacter species† 8,225 (3.35) 27 (29.35) 4,907 (7.68) 8 (4.68)
Serratia marcescens 4,879 (1.99) 9 (9.78) 3,364 (5.27) 0
Citrobacter species‡ 4,493 (1.83) 2 (2.17) 2,103 (3.29) 6 (3.51)

*CRE, carbapenem-resistant Enterobacteriaceae. CRE is defined as resistance to all tested third-generation cephalosporins (ceftriaxone, cefotaxime, or ceftazidime), and nonsusceptiblity to >1 carbapenem (ertapenem, imipenem, meropenem, or doripenem). For bacteria with intrinsic imipenem nonsusceptibility (P. mirabilis), the CRE criteria required nonsusceptibility to >2 of the carbapenems listed. ICU, intensive care unit.
E. aerogenes and E. cloacae.
C. freundii and C. koseri.

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Page created: October 29, 2015
Page updated: October 29, 2015
Page reviewed: October 29, 2015
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