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Volume 21, Number 11—November 2015
Research

Association of Higher MERS-CoV Virus Load with Severe Disease and Death, Saudi Arabia, 2014

Daniel R. Feikin, Basem M. Alraddadi, Mohammed Qutub, Omaima Shabouni, Aaron Curns, Ikwo K. Oboho, Sara M. Tomczyk, Bernard J. Wolff, John T. Watson, and Tariq A. MadaniComments to Author 
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (D.R. Feikin, A. Curns, I.K. Oboho, S.M. Tomczyk, B. Wolff, J.T. Watson); Ministry of Health, Jeddah, Saudi Arabia (B. Al-Raddadi, M. Qutub, O. Shabouni, T.A. Madani); King Faisal Specialist Hospital and Research Center, Jeddah (B. Al-Raddadi, M. Qutub); King Abdulaziz University, Jeddah (T.A. Madani)

Main Article

Table 2

Results of logistic regression for risk of death and severe outcome (death or ICU admission) for 102 patients with MERS-CoV infection, Kingdom of Saudi Arabia, 2014*

Outcome Died, n = 41, vs. survived, n = 61
 Severe, n = 48, vs. not severe, n = 54
Univariate OR (95% CI) Multivariable OR (95% CI) Univariate OR (95% CI) Multivariable OR (95% CI)
Virus load, 1 point decrease in Ct
 1.18 (1.06–1.33)
 1.17 (1.01–1.35)
1.20 (1.06–1.35)
 1.16 (1.00–1.34)
Age, y, grouped in quartiles
8–28, n = 23 Referent Referent Referent Referent
29–47, n = 21 2.67 (0.57–12.4) 2.79 (0.49–15.8) 4.10 (0.92–18.4) 5.21 (0.88–30.9)
48–60, n = 27 5.33 (1.28–22.3) 3.42 (0.68–17.1) 8.33 (2.00–34.9) 5.13 (0.98–27.0)
>60, n = 19 18.7 (3.82–91.2) 11.7 (2.00–67.9) 25.0 (4.85–129) 14.0 (2.19–89.7)
Age missing, n = 12
 6.67 (1.27–35.0)
 7.19 (1.17–44.1)
9.33 (1.76–49.6)
 12.5 (1.80–86.3)
Male sex, n = 76
 2.20 (0.83–5.84)
 NA
2.50 (0.97–6.44)
 NA
Underlying illness
No, n = 16 Referent Referent Referent Referent
Yes, n = 52 6.93 (1.76–27.4) 5.19 (1.08–25.0) 8.14 (2.25–29.5) 7.12 (1.55–32.7)
Unknown, n = 34
 0.93 (0.20–4.3)
 1.43 (0.25–8.29)
0.64 (0.15–2.70)
 0.97 (0.18–5.21)
Week of specimen collection
March 26–April 7, n = 12 Referent NA Referent NA
April 8–21, n = 45 0.57 (0.16–2.07) NA 0.44 (0.12–1.66) NA
April 22–May 5, n = 36 0.27 (0.07–1.07) NA 0.32 (0.08–1.26) NA
May 6–16, n = 9 0.57 (0.10–3.3) NA 0.63 (0.11–3.7) NA

*ORs for Ct for upE target are the odds of having outcome for each 1 point decrease in Ct. Ct, cycle threshold; ICU, intensive care unit; MERS-CoV, Middle East respiratory syndrome coronavirus; NA, not included in multivariate model; OR, odds ratio.

Main Article

Page created: October 16, 2015
Page updated: October 16, 2015
Page reviewed: October 16, 2015
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