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Volume 21, Number 12—December 2015
Dispatch

Factors Associated with Severe Leptospirosis, Martinique, 2010–2013

Patrick HochedezComments to Author , Rafaelle Theodose, Claude Olive, Pascale Bourhy, Guillaume Hurtrel, Nicolas Vignier, Hossein Mehdaoui, Ruddy Valentino, Roland Martinez, Jean-Marie Delord, Cécile Herrmann, Isabelle Lamaury, Raymond Césaire, Mathieu Picardeau, and André Cabié
Author affiliations: Centre Hospitalier Universitaire de Martinique, Fort de France, Martinique, France (P. Hochedez, R. Theodose, C. Olive, G. Hurtrel, N. Vignier, H. Mehdaoui, R. Valentino, R. Césaire, A. Cabié); Université des Antilles et de la Guyane, Fort de France, Martinique, and Pointe à Pitre, Guadeloupe, France (P. Hochedez, R. Theodose, C Olive, C. Herrmann, I. Lamaury, R. Césaire); Institut Pasteur, Paris, France (P. Bourhy, M. Picardeau); Centre Hospitalier Universitaire Avicenne, Bobigny, France (N. Vignier); Centre Hospitalier de Trinité, Trinité, Martinique (R. Martinez); Centre Hospitalier du Lamentin, Lamentin, Martinique (J.-M. Delord); Centre Hospitalier Universitaire de Pointe à Pitre, Guadeloupe (C. Herrmann, I. Lamaury); Institut National de la Santé et de la Recherche Medicale, Paris (A. Cabié)

Main Article

Table 2

Initial laboratory findings among 102 patients with quantitative PCR–confirmed leptospirosis, by disease severity, Martinique, 2010–2013

Initial laboratory findings* All patients, n = 102,
no. (%) Patients with severe disease, n = 12, no. (%) Patients with nonsevere disease, n = 90, no. (%) p value
Bilirubin
μmol/L (Q1, Q3) 20 (12, 49) 56.5 (35.5, 103) 18 (12, 38) 0.0035
>49 μmol/L, no./total (%)
25/99 (25.2)
7/12 (58.3)
18/87 (20.7)
0.01
Creatinine
μmol/L (Q1, Q3) 104 (88, 154) 169.5 (132.5, 217.5) 100 (87, 137) 0.0084
>154 μmol/L, no./total (%)
26/101 (25.7)
7/12 (58.3)
19/89 (21.3)
0.011
Urea nitrogen (mmo/Ll)
mmol/L (Q1, Q3) 5.7 (4.2, 9.3) 10.1 (8, 18.5) 5.5 (4, 8.6) 0.0068
>9.3, mmol/L, no./total (%)
21/84 (25)
4/8 (50)
17/76 (22.4)
0.103
Creatine phosphokinase
U/L (Q1, Q3) 170 (70, 443) 953 (204, 1332) 145 (64, 390) 0.0202
>443 U/L, no./total (%)
19/75 (25.3)
5/9 (55.6)
14/66 (21.2)
0.041
C-reactive protein
mg/L (Q1, Q3) 188.5 (108, 282) 338.5 (197.5, 464.5) 177.9 (89, 265) 0.0017
>282 mg/L, no./total (%)
26/102 (25.5)
7/12 (58.3)
19/90 (21.1)
0.011
Potassium, mmol/ L (Q1, Q3) 3.7 (3.4, 4.1) 3.75 (3.35, 4.15) 3.7 (3.3, 4.1) 0.8
Sodium, mmo/L (Q1, Q3)
134 (132, 136)
134 (131.5, 135)
134 (132, 136)
0.44
Aspartate aminotransferase, U/L (Q1, Q3) 61.5 (32, 102) 73.5 (59, 126.5) 57.5 (31, 102) 0.19
Alanine aminotransferase, U/L(Q1, Q3)
55 (30, 96)
49 (33.5, 74.5)
55 (30, 99)
0.69
Hemoglobin
g/dL (Q1, Q3) 13.2 (12.2, 14.5) 12.2 (11.6, 13) 13.3 (12.4, 14.7) 0.027
<12.2 g/dL, no./total (%)
26/102 (25.5)
6/12 (50)
20/90 (22.2)
0.071
Leukocytes, × 109 cells/L (Q1, Q3)
8.51 (6.2, 10.9)
10.3 (9.1, 11.4)
7.8 (6.1, 10.5)
0.07
Lymphocytes
× 109 cells/L (Q1, Q3) 0.7 (0.49, 1) 0.5 (0.2, 0.7) 0.7 (0.5, 1) 0.043
<0.49 × 109 cells/L, no./total (%)
24/92 (26)
4/8 (50)
20/84 (23.8)
0.19
Platelets
Concentration, × 109/L (Q1, Q3) 138 (92, 183) 70.5 (32.5, 115) 141 (99, 191) 0.0011
<92 × 109/L, no./total (%)
26/101 (25.7)
7/12 (58.3)
19/89 (21.3)
0.011
Prothrombin time
% (Q1, Q3) 74 (68, 90.5) 66.5 (56, 74.5) 75.5 (69, 91) 0.0166
<68%, no./total (%) 20/76 (26.3) 7/12 (58.3) 13/64 (20.3) 0.011

*Continuous variables are summarized by using median, first quartile (Q1), and third quartile (Q3). Hematologic and biochemical variables are categorized into 2 groups, using Q1 or Q3 as appropriate.

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Page created: November 17, 2015
Page updated: November 17, 2015
Page reviewed: November 17, 2015
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