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Volume 21, Number 2—February 2015

Acquisition of Human Polyomaviruses in the First 18 Months of Life

Rebecca RockettComments to Author , Seweryn Bialasiewicz, Lebogang Mhango, Jane Gaydon, Rebecca Holding, David Whiley, Stephen B. Lambert, Robert S. Ware, Michael D. Nissen, Keith Grimwood, and Theo P. Sloots
Author affiliations: Queensland Children’s Medical Research Institute, Brisbane, Queensland, Australia (R.J. Rockett, S. Bialasiewicz, L. Mhango, J. Gaydon, R. Holding, D.M. Whiley, S. B. Lambert, R.S.Ware, M.D. Nissen, K. Grimwood, T. P. Sloots); The University of Queensland, Brisbane (R.S. Ware); Queensland Health, Brisbane (S.B. Lambert); Pathology Queensland Central Laboratory, Herston, Queensland, Australia (M.D. Nissen); Griffith University, Gold Coast, Queensland, Australia (K. Grimwood); Gold Coast University Hospital, Gold Coast (K. Grimwood)

Main Article

Table 1

Detection of polyomavirus by real-time PCR in a subset of 56 ORChID study participants who had weekly anterior nasal swab specimens collected for 18 months during 2010–2014*

Characteristic WUPyV KIPyV MCPyV MWPyV
No. detections (3,851 nasal swab specimens)
No. positive/no. tested (%)
14/56 (25)
26/56 (45)
13/56 (23)
31/56 (56)
Median age at primary detection, mo (range)
11 (5.2–16.6)
10 (5.6–18.6)
7 (0.07–18.8)
13 (0.9–13.1)
Median length of viral shedding, wk (range)
2 (1–4)
2 (1–5)
1 (1)
1.2 (1–3)
Co-detection with 13 other respiratory viruses (%)
18/36 (50)
31/63 (49)
3/13 (21)
52/157 (33)
Median cycle threshold (range)† 29.45 (18–37) 30.91 (18–40) 38.58 (34–40) 35.15 (30–40)

*ORChID, Observational Research in Childhood Infectious Diseases; WUPyV, WU polyomavirus; KIPyV, KI polyomavirus; MCPyV, Merkel cell polyomavirus; MWPyV, Malawi polyomavirus.
†Cycle thresholds are approximately inversely related to viral load.

Main Article

Page created: January 21, 2015
Page updated: January 21, 2015
Page reviewed: January 21, 2015
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