Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 21, Number 4—April 2015
Research

Sequence Variability and Geographic Distribution of Lassa Virus, Sierra Leone

Tomasz A. Leski1Comments to Author , Michael G. Stockelman1, Lina M. Moses, Matthew Park, David A. Stenger, Rashid Ansumana, Daniel G. Bausch, and Baochuan Lin
Author affiliations: Naval Research Laboratory, Washington, DC, USA (T.A. Leski, M.G. Stockelman, D.A. Stenger, B. Lin); Tulane University, New Orleans, Louisiana, USA (L.M. Moses); Tulane School of Public Health and Tropical Medicine, New Orleans (L.M. Moses, D.G Bausch), Thomas Jefferson High School, Alexandria, Virginia, USA (M. Park); Mercy Hospital Research Laboratory, Bo, Sierra Leone (R. Ansumana); Liverpool School of Tropical Medicine, Liverpool, UK (R. Ansumana); Njala University, Bo (R. Ansumana)

Main Article

Table 3

Estimates of average evolutionary divergence of NP, GPC, and L gene fragments for Lassa virus strains, Sierra Leone*

Gene, grouping Difference†
Nucleotide Amino acid
NP
Overall 7.01 2.82
Clade A 5.03 2.06
Clade B 0.62 0.77
Clade C
 6.44
 2.42
GPC
Overall 8.92 4.06
Clade A 6.26 2.60
Clade B 0.68 0.49
Clade D
 7.49
 3.29
L
Overall 9.83 0.71
Clade A 6.59 0.58
Clade B 0.89 0.00
Clade D 0.88 0.00

*GPC, glycoprotein precursor; L, polymerase; NP, nucleoprotein.
†The numbers of nucleotide and amino acid differences per site from averaging over all sequence pairs or all sequence pairs within a clade multiplied by 100 are shown. All positions containing gaps and missing data were eliminated. Values for clade E defined for GPC and L sequences were not calculated because clade E contained only 1 sequence.

Main Article

1These authors contributed equally to this article.

Page created: March 17, 2015
Page updated: March 17, 2015
Page reviewed: March 17, 2015
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external