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Volume 21, Number 5—May 2015
Research

Delayed-Onset Hemolytic Anemia in Patients with Travel-Associated Severe Malaria Treated with Artesunate, France, 2011–2013

Stéphane JauréguiberryComments to Author , Marc Thellier, Papa Alioune Ndour, Flavie Ader, Camille Roussel, Romain Sonneville, Julien Mayaux, Sophie Matheron, Adela Angoulvant, Benjamin Wyplosz, Christophe Rapp, Thierry Pistone, Bénédicte Lebrun-Vignes, Eric Kendjo, Martin Danis, Sandrine Houzé, François Bricaire, Dominique Mazier, Pierre Buffet, Eric Caumes, and French Artesunate Working Group
Author affiliations: Université Pierre et Marie Curie, Paris, France (S. Jauréguiberry, M. Thellier, P.A. Ndour, C. Roussel, M. Danis, D. Mazier, P. Buffet, E. Caumes); Hôpital Pitié-Salpêtrière, Assistance Publique des Hôpitaux de Paris (APHP), Paris (S. Jauréguiberry, M. Thellier, F. Ader, J. Mayaux, B. Lebrun-Vignes, M. Danis, F. Bricaire, D. Mazier, P. Buffet, E. Caumes); Centre National de Référence du Paludisme, Paris (S. Jauréguiberry, M. Thellier, E. Kendjo, M. Danis, D. Mazier, P. Buffet); Hôpital Bichat, APHP, Paris (R. Sonneville, S. Matheron, S. Houzé); Université Paris-Sud, Orsay, France (A. Angoulvant); Hôpital de Bicêtre, Le Kremlin Bicêtre, APHP, France (A. Angoulvant, B. Wyplosz); Hôpital d’Instruction des Armées Begin, St. Mandé, France (C. Rapp); Hôpital Pellegrin, Bordeaux, France (T. Pistone)

Main Article

Figure 3

Typical features of postartesunate delayed-onset hemolysis and anemia for 21 patients followed in a prospective analysis of delayed-onset hemolytic anemia in patients with severe imported malaria treated with artesunate, France, 2011–2013. During the second and third weeks of late hemolytic anemia, a drop in hemoglobin occurred along with a reoccurrence of markers of hemolysis (defined as >10% drop in hemoglobin level or >10% rise in LDH concentration). Reticulocyte regeneration occurred d

Figure 3. Typical features of postartesunate delayed-onset hemolysis and anemia for 21 patients followed in a prospective analysis of delayed-onset hemolytic anemia in patients with severe imported malaria treated with artesunate, France, 2011–2013. During the second and third weeks of late hemolytic anemia, a drop in hemoglobin occurred along with a reoccurrence of markers of hemolysis (defined as >10% drop in hemoglobin level or >10% rise in LDH concentration). Reticulocyte regeneration occurred during week 3 (delayed in comparison with other patterns of anemia, in which regeneration usually occurs during week 2 [not shown]). Values are means (SEMs). LDH, lactate dehydrogenase.

Main Article

1Members of the French Artesunate Working Group are listed in the Technical Appendix.

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