Volume 21, Number 5—May 2015
Research
Protective Antibodies against Placental Malaria and Poor Outcomes during Pregnancy, Benin
, Lise Denoeud-Ndam, Justin Doritchamou, Firmine Viwami, Ali Salanti, Morten A. Nielsen, Nadine Fievet, Achille Massougbodji, Adrian J.F. Luty, and Philippe Deloron
Table 4
Association between inhibition capacity at delivery and 4 outcomes in 309 women with documented Plasmodium falciparum infection during follow-up, Benin*
| IBA levels at delivery, % inhibition | Placental malaria† |
Low birthweight‡ |
SGA |
Preterm birth† |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | p value | OR (95% CI) | p value | OR (95% CI) | p value | OR (95% CI) | p value | ||||
| Overall sample | NA | NA | n = 290 | 0.028 | n = 264 | 0.0084 | NA | NA | |||
| Second quartile, 28–43 | NA | NA | 0.39 (0.15–1.01) | NA | 0.22 (0.08–0.59) | NA | NA | NA | |||
| Third quartile, 43–63 | NA | NA | 0.27 (0.10–0.76) | NA | 0.34 (0.13–0.88)§ | NA | NA | NA | |||
| Higher quartile, >63 |
NA |
NA |
0.22
(0.07–0.72) |
NA |
0.35
(0.13–0.94)§ |
NA |
NA |
NA |
|||
| Women not infected at inclusion (first infection after inclusion) | n = 163 | 0.0085 | NA | NA | NA | NA | n = 173 | 0.0324 | |||
| Second quartile, 28–43 | 0.66 (0.22–2.04) | NA | NA | NA | NA | NA | 0.10 (0.01–0.93)§ | NA | |||
| Third quartile, 43–63 | 0.19 (0.05–0.72)§ | NA | NA | NA | NA | NA | 0.09 (0.01–0.89)§ | NA | |||
| Higher quartile, >63 |
0.21
(0.06–0.76)§ |
NA |
NA |
NA |
NA |
NA |
0.18
(0.03–1.18) |
NA |
|||
| Women infected at inclusion | n = 103 | 0.604 | NA | NA | NA | NA | n = 87 | 0.969 | |||
| Second quartile, 28–43 | 1.29 (0.30–5.50) | NA | NA | NA | NA | NA | 0.68 (0.14–3.20) | NA | |||
| Third quartile, 43–63 | 2.02 (0.52–7.91) | NA | NA | NA | NA | NA | 0.87 (1.96–3.83) | NA | |||
| Higher quartile, >63 | 0.90 (0.19–4.35) | NA | NA | NA | NA | NA | NA | NA | |||
*SGA, small for gestational age; OR, odds ratio; IBA, inhibition of binding assay; NA, not applicable. Analysis was conducted by using multivariate logistic regression adjusting for center, gravidity, infection at inclusion, and testing the interaction between IBA level and infection at inclusion.
†In the absence of a major interaction, results of the model without interaction are shown.
‡In the instance of a major interaction, results were stratified by the presence or absence of infection at inclusion.
§When ORs for 2 contiguous quartiles were similar, p values were computed after grouping those quartiles.