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Volume 21, Number 5—May 2015

Protective Antibodies against Placental Malaria and Poor Outcomes during Pregnancy, Benin

Nicaise Tuikue NdamComments to Author , Lise Denoeud-Ndam, Justin Doritchamou, Firmine Viwami, Ali Salanti, Morten A. Nielsen, Nadine Fievet, Achille Massougbodji, Adrian J.F. Luty, and Philippe Deloron
Author affiliations: Institut de Recherche pour le Développement, Paris, France (N. Tuikue Ndam, L. Denoeud-Ndam, J. Doritchamou, N. Fievet, A.J.F. Luty, P. Deloron); Pôle de Recherche et d’Enseignement Supérieur Sorbonne Paris Cité, Paris (N.Tuikue Ndam, N. Fievet, A.J.F. Luty, P. Deloron),; Université d’Abomey-Calavi, Cotonou, Benin (F. Viwami, A. Massougbodji, A.J.F. Luty); University of Copenhagen, Copenhagen, Denmark (A. Salanti, M.A. Nielsen)

Main Article

Table 4

Association between inhibition capacity at delivery and 4 outcomes in 309 women with documented Plasmodium falciparum infection during follow-up, Benin*

IBA levels at delivery, % inhibition Placental malaria†
Low birthweight‡
Preterm birth†
OR (95% CI) p value OR (95% CI) p value OR (95% CI) p value OR (95% CI) p value
Overall sample NA NA n = 290 0.028 n = 264 0.0084 NA NA
Second quartile, 28–43 NA NA 0.39
(0.15–1.01) NA 0.22
(0.08–0.59) NA NA NA
Third quartile, 43–63 NA NA 0.27
(0.10–0.76) NA 0.34
(0.13–0.88)§ NA NA NA
Higher quartile, >63



Women not infected at inclusion (first infection 
after inclusion) n = 163 0.0085 NA NA NA NA n = 173 0.0324
Second quartile, 28–43 0.66
(0.22–2.04) NA NA NA NA NA 0.10
(0.01–0.93)§ NA
Third quartile, 43–63 0.19
(0.05–0.72)§ NA NA NA NA NA 0.09
(0.01–0.89)§ NA
Higher quartile, >63



Women infected at inclusion n = 103 0.604 NA NA NA NA n = 87 0.969
Second quartile, 28–43 1.29 
(0.30–5.50) NA NA NA NA NA 0.68
(0.14–3.20) NA
Third quartile, 43–63 2.02 
(0.52–7.91) NA NA NA NA NA 0.87
(1.96–3.83) NA
Higher quartile, >63 0.90 
(0.19–4.35) NA NA NA NA NA NA NA

*SGA, small for gestational age; OR, odds ratio; IBA, inhibition of binding assay; NA, not applicable. Analysis was conducted by using multivariate logistic regression adjusting for center, gravidity, infection at inclusion, and testing the interaction between IBA level and infection at inclusion.
†In the absence of a major interaction, results of the model without interaction are shown.
‡In the instance of a major interaction, results were stratified by the presence or absence of infection at inclusion.
§When ORs for 2 contiguous quartiles were similar, p values were computed after grouping those quartiles.

Main Article

Page created: April 17, 2015
Page updated: April 17, 2015
Page reviewed: April 17, 2015
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