TY - JOUR AU - Ceesay, Serign AU - Koivogui, Lamine AU - Nahum, Alain AU - Taal, Makie Abdoulie AU - Okebe, Joseph AU - Affara, Muna AU - Kaman, Lama Eugène AU - Bohissou, Francis AU - Agbowai, Carine AU - Tolno, Benoit Gniouma AU - Amambua-Ngwa, Alfred AU - Bangoura, NFaly AU - Ahounou, Daniel AU - Muhammad, Abdul Khalie AU - Duparc, Stephan AU - Hamed, Kamal AU - Ubben, David AU - Bojang, Kalifa AU - Achan, Jane AU - D’Alessandro, Umberto T1 - Malaria Prevalence among Young Infants in Different Transmission Settings, Africa T2 - Emerging Infectious Disease journal PY - 2015 VL - 21 IS - 7 SP - 1114 SN - 1080-6059 AB - The prevalence and consequences of malaria among infants are not well characterized and may be underestimated. A better understanding of the risk for malaria in early infancy is critical for drug development and informed decision making. In a cross-sectional survey in Guinea, The Gambia, and Benin, countries with different malaria transmission intensities, the overall prevalence of malaria among infants <6 months of age was 11.8% (Guinea, 21.7%; The Gambia, 3.7%; and Benin, 10.2%). Seroprevalence ranged from 5.7% in The Gambia to 41.6% in Guinea. Mean parasite densities in infants were significantly lower than those in children 1–9 years of age in The Gambia (p<0.0001) and Benin (p = 0.0021). Malaria in infants was significantly associated with fever or recent history of fever (p = 0.007) and anemia (p = 0.001). Targeted preventive interventions, adequate drug formulations, and treatment guidelines are needed to address the sizeable prevalence of malaria among young infants in malaria-endemic countries. KW - Malaria KW - young infants KW - transmission intensity KW - Africa KW - transmission settings KW - epidemiology KW - parasite KW - prevalence KW - anemia KW - parasites DO - 10.3201/eid2107.142036 UR - https://wwwnc.cdc.gov/eid/article/21/7/14-2036_article ER - End of Reference