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Volume 21, Number 8—August 2015
Synopsis

Real-Time Microbiology Laboratory Surveillance System to Detect Abnormal Events and Emerging Infections, Marseille, France

Cédric Abat, Hervé Chaudet, Philippe Colson, Jean-Marc Rolain, and Didier RaoultComments to Author 
Author affiliations: Aix-Marseille Université, Marseille, France (C. Abat, P. Colson, J.-M. Rolain, D. Raoult); Sciences Economiques et Sociales de la Santé et Traimtement de l’Information Médicale (SESSTIM), Marseille (H. Chaudet)

Main Article

Table 4

Validated alarms emitted by MARSS and investigations from May 21, 2013, through June 4, 2014, Marseille, France*

Pathogen Alarm date Abnormal event observed Investigation Result Intervention
Klebsiella pneumoniae 2013 Jul 9 Isolation from 1 patient of K. pneumoniae strain that seemed to produce carbapenemases Additional antibiotic susceptibility testing confirmed that strain was carbapenemase producing True alarm Patient isolated and resport sent to ARS
K. pneumoniae 2013 Jul 30 Isolation from 1 patient of K. pneumoniae strain that seemed to produce carbapenemases Additional antibiotic susceptibility testing confirmed that strain was carbapenemase producing True alarm Patient isolated and resport sent to ARS
K. pneumoniae 2013 Aug 20 Abnormal increase in no. strains with ESBLphenotype Additional investigations led to conclusion that increase was due to a technical problem in MARSS False alarm Technical problem was immediately corrected
K. pneumoniae 2013 Sep 9 Isolation from 1 patient of K. pneumoniae strain that seemed to produce carbapenemases Additional antibiotic susceptibility testing confirmed that strain was carbapenemase producing True alarm Patient isolated and resport sent to ARS
Salmonella spp. 2013 Sep 10 3 strains isolated from 3 patients Additional investigations did not identify any links between infected patients False alarm No intervention
K. pneumoniae 2013 Sep 10 Isolation from 1 patient of K. pneumoniae strain that seemed to produce carbapenemases Additional antibiotic susceptibility testing confirmed that strain was carbapenemase producing True alarm Patient isolated and resport sent to ARS
Citrobacter koseri 2013 Sep 17 Various strains isolated with same antibiotic-resistance profile Additional investigations did not identify any links between infected patients False alarm No intervention
Enterobacter cloacae 2013 Sep 20 Isolation from 1 patient of E. cloacae strain that seemed to produce carbapenemases Additional antibiotic susceptibility testing confirmed that strain was carbapenemase producing True alarm Patient isolated and resport sent to ARS
K. pneumoniae 2013 Sep 24 Isolation from 1 patient of K. pneumoniae strain that seemed to produce carbapenemases Additional antibiotic susceptibility testing confirmed that strain was carbapenemase producing True alarm Patient isolated and resport sent to ARS
Enterobacter aerogenes 2013 Oct 4 Isolation from 1 patient of E. aerogenes strain that seemed to produce carbapenemases Additional antibiotic susceptibility testing confirmed that strain was carbapenemase producing True alarm Patient isolated and resport sent to ARS
Staphylococcus epidermidis 2013 Oct 8 Abnormal increase in no. S. epidermidis strains highly resistant to methicillin Additional investigations did not identify any links between infected patients, and no clones were identified with MALDI-TOF spectra analysis False alarm No intervention
Salmonella spp. 2013 Oct 8 Abnormal increase in no. strains isolated from patients hospitalized in same hospital Additional investigations did not identify any links between infected patients, and no clones were identified by MALDI-TOF spectra analysis False alarm No intervention
K. pneumoniae 2013 Oct 15 Isolation from 1 patient of K. pneumoniae strain that seemed to produce carbapenemases Additional antibiotic susceptibility testing confirmed that strain was carbapenemase producing True alarm Patient isolated and resport sent to ARS
K. pneumoniae 2013 Oct 15 Isolation from 1 patient of K. pneumoniae strain that seemed to produce carbapenemases Additional antibiotic susceptibility testing confirmed that strain was carbapenemase producing True alarm Patient isolated and resport sent to ARS
K. pneumoniae 2013 Nov 22 Isolation from 1 patient of K. pneumoniae strain that seemed to produce carbapenemases Additional antibiotic susceptibility testing confirmed that strain was carbapenemase producing True alarm Patient isolated and resport sent to ARS
K. pneumoniae 2013 Dec 10 Abnormal increase in no. strains with ESBL resistance phenotype Additional investigations did not identify any links between infected patients, and no clones were identified by MALDI-TOF spectra analysis False alarm No intervention
K. pneumoniae 2013 Jan 3 Isolation from 1 patient of K. pneumoniae strain that seemed to produce carbapenemases Additional antibiotic susceptibility testing confirmed that strain was carbapenemase producing True alarm Patient isolated and report sent to ARS
E. cloacae 2014 Jan 7 Abnormal increase in no. E. cloacae strains with wild resistance phenotype isolated for week of 2013 Nov 25p[ Additional investigations did not identify any links between infected patients, and no clones were identified by MALDI-TOF spectra analysis False alarm No intervention
Morganella morganii 2014 Jan 7 Abnormal increase in no. M. morganii strains isolated with inhibitor-resistant penicillinase phenotype Additional investigation allowed us to conclude it was a wild phenotype strain False alarm No intervention
Pseudomonas aeruginosa 2014 Jan 7 Abnormal increase in no. P. aeruginosa strains with wild-type resistance phenotype isolated for 28/10/2013 week Additional investigations did not identify any links between infected patients, and no clones were identified by MALDI-TOF spectra analysis False alarm No intervention
K. pneumoniae 2014 Jan 21 Isolation from 1 patient of K. pneumoniae strain that seemed to produce carbapenemases Additional antibiotic susceptibility testing confirmed that strain was carbapenemase producing True alarm Patient isolated and resport sent to ARS
Proteus mirabilis 2014 Jan 25 Isolation from 1 patient of P. mirabilis strain that seemed to produce carbapenemases Additional antibiotic susceptibility testing did not confirm that strain was carbapenemase producing False alarm No intervention
Enterobacter aerogenes 2014 Apr 8 Abnormal increase in no. strains with high level cephalosporinase resistance phenotype Additional investigations did not identify any links between infected patients, and no clones were identified with MALDI-TOF spectra analysis False alarm No intervention
Escherichia coli 2014 Apr 8 Abnormal increase in no. strains with inhibitor-resistant penicillinase phenotype Additional investigations did not identify any links between infected patients, and no clones were identified with MALDI-TOF spectra analysis False alarm No intervention
P. mirabilis 2014 Apr 8 Abnormal increase in no. strains with wild phenotype Additional investigations did not identify infected patients, and no clones were identified with MALDI-TOF spectra analysis False alarm No intervention
Streptococcus agalactiae 2014 Apr 8 Abnormal increase in no. strains with methicillin-resistant phenotype Additional investigations did not identify any links between infected patients, and no clones were identified with MALDI-TOF spectra analysis False alarm No intervention
E. coli 2014 Apr 8 Abnormal increase in no. strains with inhibitor-resistant phenotype Additional MALDI-TOF spectra analysis did not identify clones True alarm No explanations were found. First results from ongoing investigations show that most infections come from community-acquired urinary tract infections in women
E. cloacae 2014 Apr 8 Isolation from 1 patient of E. cloacae strain that seemed to produce carbapenemases Additional antibiotic susceptibility testing confirmed that strain was carbapenemase producing True alarm Patient isolated and resport sent to ARS
K. pneumoniae 2014 May 21 Isolation from 1 patient of K. pneumoniae strain that seemed to produce carbapenemases Additional antibiotic susceptibility testing confirmed that strain was carbapenemase producing True alarm Patient isolated and resport sent to ARS
Serratia marcescens 2014 Jun 3 Isolation from 1 patient of S. marcescens strain that seemed to produce carbapenemases Additional antibiotic susceptibility testing did not confirm that strain was carbapenemase producing False alarm No intervention
P. mirabilis 2014 Jun 4 Isolation from 1 patient of P. mirabilis strain that seemed to produce carbapenemases Additional antibiotic susceptibility testing confirmed that strain was carbapenemase producing True alarm Patient isolated and resport sent to ARS

*MARSS, Marseille Antibiotic Resistance Surveillance System; ESBL, extended spectrum β-lactamase;ARS, MALDI-TOF, matrix-assisted laser desorption ionization time of flight; ARS, Agence Régionale de Santé.

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Page created: July 14, 2015
Page updated: July 14, 2015
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