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Volume 22, Number 1—January 2016

Waterborne Elizabethkingia meningoseptica in Adult Critical Care1

Luke S.P. MooreComments to Author , Daniel S. Owens, Annette Jepson, Jane F. Turton, Simon Ashworth, Hugo Donaldson, and Alison H. Holmes
Author affiliations: Imperial College Healthcare NHS Trust, London, UK (L.S.P. Moore, A. Jepson, S. Ashworth, H. Donaldson, A.H. Holmes); Imperial College London, London. (L.S.P. Moore, A.H. Holmes); St. George’s Healthcare NHS Trust, London (D.S. Owens); Public Health England, London (J.F. Turton)

Main Article

Table 2

MICs of selected antimicrobial agents tested against a representative isolate from an Elizabethkingia meningoseptica outbreak strain from an adult critical care unit, West London, UK, 2012–2013*

Antimicrobial agent MIC, mg/L Interpretation
Ceftazidime 256 Nonsusceptible
Piperacillin/tazobactam 16 Susceptible
Meropenem >32 Nonsusceptible
Imipenem 64 Nonsusceptible
Aztreonam >64 Nonsusceptible
Gentamicin 16 Nonsusceptible
Tobramycin >32 Nonsusceptible
Amikacin 32 Nonsusceptible
Colistin >32 Nonsusceptible
Ciprofloxacin 1 Intermediate
Minocycline 0.5 Unknown
Trimethoprim/sulfamethoxazole 0.25 Susceptible

*MICs were determined by serial agar dilution by using established methods (24). Interpretation of MICs used established British Society of Chemotherapy breakpoints. The intrinsic metallo- and extended-spectrum-β-lactamases exhibited by E. meningoseptica mean the apparent in vitro susceptibility of the organism to piperacillin/tazobactam should be viewed with caution.

Main Article

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Main Article

1Preliminary findings of this study were presented, in part, at the 27th European Society for Intensive Care Medicine conference, Barcelona, Spain, September 27– October 1, 2014.

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