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Volume 22, Number 1—January 2016

Variations in Spike Glycoprotein Gene of MERS-CoV, South Korea, 2015

Dae-Won Kim1, You-Jin Kim1, Sung Han Park, Mi-Ran Yun, Jeong-Sun Yang, Hae Ji Kang, Young Woo Han, Han Saem Lee, Heui Man Kim, Hak Kim, A-Reum Kim, Deok Rim Heo, Su Jin Kim, Jun Ho Jeon, Deokbum Park, Joo Ae Kim, Hyang-Min Cheong, Jeong-Gu Nam, Kisoon Kim, and Sung Soon KimComments to Author 
Author affiliations: Korea Centers for Disease Control and Prevention, Cheongju-si, South Korea

Main Article

Table 2

Genetic changes in spike glycoprotein gene sequences strain-specific variants of MERS-CoV from South Korea compared with those of other MERS-CoV isolates*

Virus isolate
Nucleotide (amino acid) positions
NTD RBD Other regions
183 258 409 1586 1588 1848 1886 3177 3267
JX869059_HCoV-EMC_2012 C (G) T (V) A (S) T (I) G (V) T (V) G (R) T (D) C (S)
KT026453_KSA_Hu/Riyadh_KSA-2959_2015 C (V)
Riyadh_KKUH_0734_20150218 C (V)
Riyadh_KKUH_0756_20150223 C (V)
Riyadh_KKUH_0780_20150225 C (V)
KT026454_KSA_Hu/Riyadh_KSA_4050_2015 C (V)
Riyadh_KKUH_0944_20150302 C (V)
Riyadh_KKUH_1066_20150303 C (V)
Riyadh_KKUH_1080_20150303 C (V)
Riyadh_KKUH_1145_20150304 C (V)
Riyadh_KKUH_1470_20150308 C (V)
MERS-CoV/KOR/KNIH/001_05_2015 [PAT001] C (V) C (T) C (D) C (S)
MERS-CoV/KOR/KNIH/009_05_2015 [PAT009] C (V) C (V) C (D) C (S)
ChinaGD01_2015 [PAT010]† G (C) C (V) C (V) C (D) C (S)
MERS-CoV/KOR/KNIH/012_05_2015 [PAT012] C (V) C (T) C (V) C (D) C (S)
MERS-CoV/KOR/KNIH/013_05_2015 [PAT013] C (V) C (T) C (V) C (D) C (S)
MERS-CoV/KOR/KNIH/015_05_2015 [PAT015] C (V) C (T) C (V) C (D) C (S)
MERS-CoV/KOR/KNIH/042_05_2015 [PAT042] C (V) C (T) C (V) A (H) C (D) T (S)
MERS-CoV/KOR/KNIH/002_05_2015 [PAT002]‡ C (V) C (R) C (L) C (D) T (S)

*Alphanumeric codes in brackets indicate patient (PAT) number. Dots indicate no change in sequence identity. MERS-CoV, Middle East respiratory syndrome coronavirus; NTD, N-terminal domain; RBD, receptor-binding domain. Dots indicate sequence identity.
†MERS-CoV strain ChinaGD01 (KT006149).
‡Third-passage isolate from Vero cells.

Main Article

1These authors contributed equally to this article.

Page created: December 18, 2015
Page updated: December 18, 2015
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