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Volume 22, Number 1—January 2016
Research

Multifacility Outbreak of Middle East Respiratory Syndrome in Taif, Saudi Arabia

Abdullah M. Assiri, Glen R. AbediComments to Author , Abdulaziz A. Bin Saeed, Mutwakil A. Abdalla, Malak al-Masry, Abdul Jamil Choudhry, Xiaoyan Lu, Dean D. Erdman, Kathleen Tatti, Alison M. Binder, Jessica M. Rudd, Jerome I. Tokars, Congrong Miao, Hussain Alarbash, Randa Nooh, Mark A. Pallansch, Susan I. Gerber, and John T. Watson
Author affiliations: Ministry of Health, Riyadh, Saudi Arabia (A. Assiri, A.A. Bin Saeed, M. al-Masry); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (G.R. Abedi, X. Lu, D.D. Erdman, K. Tatti, A.M. Binder, J. Rudd, J. Tokars, C. Miao, M. Pallansch, S.I. Gerber, J.T. Watson); Taif Governorate Health Directorate, Taif, Saudi Arabia (M.A. Abdalla); Field Epidemiology Training Program, Ministry of Health, Riyadh (A.J. Choudhry, H. Alarbash, R. Nooh)

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Figure 2

Midpoint-rooted phylogenetic tree inferred from multiple-sequence alignment of 10 new cases of Middle East respiratory syndrome coronavirus (MERS-CoV) spike open reading frame sequences (4,062 nt) from Taif, Saudi Arabia (brackets). Colored circles identify healthcare facilities; numbers indicate individual patients. Taif sequences are shown in context with the closest related sequences that comprise the Hafr-Al-Batin_1 clade, as originally defined by Cotton et al. (17), and with sequences relat

Figure 2. Midpoint-rooted phylogenetic tree inferred from multiple-sequence alignment of 10 new cases of Middle East respiratory syndrome coronavirus (MERS-CoV) spike open reading frame sequences (4,062 nt) from Taif, Saudi Arabia (brackets). Colored circles identify healthcare facilities; numbers indicate individual patients. Taif sequences are shown in context with the closest related sequences that comprise the Hafr-Al-Batin_1 clade, as originally defined by Cotton et al. (17), and with sequences related to the 2015 outbreak event in South Korea. For clarity, the remaining published sequences are collapsed into triangles. Published sequences are designated by GenBank accession number, strain name, and month and year of sample collection. The estimated neighbor-joining tree was constructed from nucleotide alignments by using MEGA version 6.06 (http://www.megasoftware.net). Bootstrap support values (1,000 replicates) ≥70% are plotted at the indicated internal branch nodes. Scale bar shows the genetic distance as the number of nucleotide substitutions per site. KSA, Kingdom of Saudi Arabia.

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