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Volume 22, Number 10—October 2016
CME ACTIVITY - Synopsis

Infection-Related Death among Persons with Refractory Juvenile Idiopathic Arthritis

Mario AbinunComments to Author , Jonathan P. Lane, Mark Wood1, Mark Friswell, Terence J. Flood, and Helen E. Foster
Author affiliations: Great North Children's Hospital, Newcastle upon Tyne, UK (M. Abinun, J.P. Lane, M. Friswell, T.J. Flood, H.E. Foster); Newcastle University, Newcastle upon Tyne (M. Abinun, H.E. Foster); Leeds General Infirmary, Leeds, UK (M. Wood)

Main Article

Table 2

Laboratory parameters of inflammatory activity for 2 children with juvenile idiopathic arthritis, Newcastle upon Tyne, United Kingdom, 2004*

Patient no., date CRP, mg/dL Ne, × 109 cells/L PLT, × 109/L ESR, mm/h Ferr, μg/L Fib, g/L TG, mmol/L Alb, g/L ALT, U/L Na, mmol/L
Patient 1
Feb 17 100 20.2 322 35 485 5.4 0.7 34 24 142
Feb 28 107 28.5 266 31 35 136
Feb 29 157 15.8 140 22 48 134
Mar 1
63
7.1
79




23
120
140
Patient 2
May 27 122 17.2 475 45 339 6.3 1.9 44 10 135
Jun 1 260 34.9 603 2815 8.0 38 23 137
Jun 6 365 37.5 710 105 7692 8.1 37 50 134
Jun 10 127 70.5 244 2.9 13 125 134

*Laboratory parameters for diagnosing macrophage activation syndrome: Ferr >684 μg/L and any 2 of the following signs: PLT count <181 × 109/L, ALT >48 U/L, TG >156 mg/dL, fibrinogen <360 mg/dL (14). See section in text on MAS versus Multiorgan Failure. Alb, serum albumin level (reference 38–53 g/L); ALT, serum alanine transaminase level (reference 0–40 U/L); CRP, C-reactive protein (reference 0–5 mg/dL); ESR, erythrocyte sedimentation rate (Westergren; reference 110 mm/h); Ferr, serum ferritin level (reference 20–60 μg/L); Fib, serum fibrinogen level (reference 1.5–4.0 g/L); Na, serum sodium level (reference 135–145 mmol/L); Ne, absolute neutrophil count; PLT, absolute platelet count; TG, serum triglyceride level (reference 0.5–1.8).

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References
  1. Prakken  B, Albani  S, Martini  A. Juvenile idiopathic arthritis. Lancet. 2011;377:213849.DOIPubMedGoogle Scholar
  2. Hinze  C, Gohar  F, Foell  D. Management of juvenile idiopathic arthritis: hitting the target. Nat Rev Rheumatol. 2015;11:290300.DOIPubMedGoogle Scholar
  3. Ringold  S, Weiss  PF, Beukelman  T, Dewitt  EM, Ilowite  NT, Kimura  Y, ; American College of Rheumatology. 2013 update of the 2011 American College of Rheumatology recommendations for the treatment of juvenile idiopathic arthritis: recommendations for the medical therapy of children with systemic juvenile idiopathic arthritis and tuberculosis screening among children receiving biologic medications. Arthritis Care Res (Hoboken). 2013;65:155163.DOIPubMedGoogle Scholar
  4. Southwood  TR. Paediatric rheumatic disease: Treatment of JIA in the biologic era: what are we waiting for? Nat Rev Rheumatol. 2014;10:1324.DOIPubMedGoogle Scholar
  5. Otten  MH, Prince  FH, Anink  J, Ten Cate  R, Hoppenreijs  EP, Armbrust  W, Effectiveness and safety of a second and third biological agent after failing etanercept in juvenile idiopathic arthritis: results from the Dutch National ABC Register. Ann Rheum Dis. 2013;72:7217.DOIPubMedGoogle Scholar
  6. Record  JL, Beukelman  T, Cron  RQ. Combination therapy of abatacept and anakinra in children with refractory systemic juvenile idiopathic arthritis: a retrospective case series. J Rheumatol. 2011;38:1801.DOIPubMedGoogle Scholar
  7. Woerner  A, Ritz  N. Infections in children treated with biological agents. Pediatr Infect Dis J. 2013;32:2848.DOIPubMedGoogle Scholar
  8. Hashkes  PJ, Uziel  Y, Laxer  RM. The safety profile of biologic therapies for juvenile idiopathic arthritis. Nat Rev Rheumatol. 2010;6:56171.DOIPubMedGoogle Scholar
  9. Abinun  M. Haematopoietic stem cell transplantation for rheumatological conditions. Paediatr Child Health. 2011;21:55862 .DOIGoogle Scholar
  10. Abinun  M, Flood  TJ, Cant  AJ, Veys  P, Gennery  AR, Foster  HE, Autologous T cell depleted haematopoietic stem cell transplantation in children with severe juvenile idiopathic arthritis in the UK (2000-2007). Mol Immunol. 2009;47:4651.DOIPubMedGoogle Scholar
  11. Milanetti  F, Abinun  M, Voltarelli  JC, Burt  RK. Autologous hematopoietic stem cell transplantation for childhood autoimmune disease. Pediatr Clin North Am. 2010;57:23971.DOIPubMedGoogle Scholar
  12. Myers  A, Clark  J, Foster  H. Tuberculosis and treatment with infliximab. N Engl J Med. 2002;346:6236.DOIPubMedGoogle Scholar
  13. Consolaro  A, Ruperto  N, Bracciolini  G, Frisina  A, Gallo  MC, Pistorio  A, ; Paediatric Rheumatology International Trials Organization (PRINTO). Defining criteria for high disease activity in juvenile idiopathic arthritis based on the juvenile arthritis disease activity score. Ann Rheum Dis. 2014;73:13803.DOIPubMedGoogle Scholar
  14. Ravelli  A, Minoia  F, Davì  S, Horne  A, Bovis  F, Pistorio  A, 2016 classification criteria for MAS complicating SO-JIA: EULAR/ACR/PPRINTO Initiative. Arthritis Rheumatol. 2016;68:56676.DOIPubMedGoogle Scholar
  15. Mermel  LA, Allon  M, Bouza  E, Craven  DE, Flynn  P, O’Grady  NP, Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection: 2009 Update by the Infectious Diseases Society of America.[ [Erratum in: Clin Infect Dis. 2010;50:457. Erratum in: Clin Infect Dis. 2010;50:1079. ]. Clin Infect Dis. 2009;49:145.DOIPubMedGoogle Scholar
  16. Minoia  F, Davì  S, Horne  A, Demirkaya  E, Bovis  F, Li  C, ; Pediatric Rheumatology International Trials Organization; Childhood Arthritis and Rheumatology Research Alliance; Pediatric Rheumatology Collaborative Study Group; Histiocyte Society. Clinical features, treatment, and outcome of macrophage activation syndrome complicating systemic juvenile idiopathic arthritis: a multinational, multicenter study of 362 patients. Arthritis Rheumatol. 2014;66:31609.DOIPubMedGoogle Scholar
  17. Lovell  DJ, Zaoutis  TE, Sullivan  K. Immunosuppressants, infection, and inflammation. Clin Immunol. 2004;113:1379.DOIPubMedGoogle Scholar
  18. Beukelman  T, Xie  F, Chen  L, Baddley  JW, Delzell  E, Grijalva  CG, ; SABER Collaboration. Rates of hospitalized bacterial infection associated with juvenile idiopathic arthritis and its treatment. Arthritis Rheum. 2012;64:277380.DOIPubMedGoogle Scholar
  19. Kimura  Y, Weiss  JE, Haroldson  KL, Lee  T, Punaro  M, Oliveira  S, ; Childhood Arthritis Rheumatology Research Alliance Carra Net Investigators. Pulmonary hypertension and other potentially fatal pulmonary complications in systemic juvenile idiopathic arthritis. Arthritis Care Res (Hoboken). 2013;65:74552.DOIPubMedGoogle Scholar
  20. van de Vosse  E, van Dissel  JT, Ottenhoff  TH. Genetic deficiencies of innate immune signalling in human infectious disease. Lancet Infect Dis. 2009;9:68898.DOIPubMedGoogle Scholar
  21. Abinun  M. An overview of infectious complications in children on new biologic response-modifying agents. Ped Health. 2010;4:50917 .DOIGoogle Scholar
  22. Maródi  L, Casanova  JL. Primary immunodeficiencies may reveal potential infectious diseases associated with immune-targeting mAb treatments. J Allergy Clin Immunol. 2010;126:9107.DOIPubMedGoogle Scholar
  23. Puel  A, Picard  C, Lorrot  M, Pons  C, Chrabieh  M, Lorenzo  L, Recurrent staphylococcal cellulitis and subcutaneous abscesses in a child with autoantibodies against IL-6. J Immunol. 2008;180:64754.DOIPubMedGoogle Scholar
  24. Swart  JF, de Roock  S, Wulffraat  NM. What are the immunological consequences of long-term use of biological therapies for juvenile idiopathic arthritis? Arthritis Res Ther. 2013;15:213.DOIPubMedGoogle Scholar
  25. Fitch  PG, Cron  RQ. Septic abscess in a child with juvenile idiopathic arthritis receiving anti-tumor necrosis factor-alpha. J Rheumatol. 2006;33:825, author reply 826–7.PubMedGoogle Scholar
  26. Renaud  C, Ovetchkine  P, Bortolozzi  P, Saint-Cyr  C, Tapiero  B. Fatal group A Streptococcus purpura fulminans in a child receiving TNF-α blocker. Eur J Pediatr. 2011;170:65760.DOIPubMedGoogle Scholar
  27. Toussi  SS, Pan  N, Walters  HM, Walsh  TJ. Infections in children and adolescents with juvenile idiopathic arthritis and inflammatory bowel disease treated with tumor necrosis factor-α inhibitors: systematic review of the literature. Clin Infect Dis. 2013;57:131830.DOIPubMedGoogle Scholar
  28. Elwood  RL, Pelszynski  MM, Corman  LI. Multifocal septic arthritis and osteomyelitis caused by group A Streptococcus in a patient receiving immunomodulating therapy with etanercept. Pediatr Infect Dis J. 2003;22:2868.DOIPubMedGoogle Scholar
  29. Henderson  C, Goldbach-Mansky  R. Monogenic IL-1 mediated autoinflammatory and immunodeficiency syndromes: finding the right balance in response to danger signals. Clin Immunol. 2010;135:21022.DOIPubMedGoogle Scholar
  30. Cole  TS, Rogerson  E, Collins  J, Galloway  A, Clark  J. Central venous catheter-related blood stream infections in children undergoing hematopoietic stem cell transplant for primary immunodeficiency and other nonmalignant disorders. Pediatr Infect Dis J. 2011;30:1098100.DOIPubMedGoogle Scholar
  31. Eleftheriou  D, Melo  M, Marks  SD, Tullus  K, Sills  J, Cleary  G, Biologic therapy in primary systemic vasculitis of the young. Rheumatology (Oxford). 2009;48:97886.DOIPubMedGoogle Scholar
  32. Russell  RK, Wilson  ML, Loganathan  S, Bourke  B, Kiparissi  F, Mahdi  G, A British Society of Paediatric Gastroenterology, Hepatology and Nutrition survey of the effectiveness and safety of adalimumab in children with inflammatory bowel disease. Aliment Pharmacol Ther. 2011;33:94653.DOIPubMedGoogle Scholar
  33. Radhakrishna  SM, Reiff  AO, Marzan  KA, Azen  C, Khemani  RG, Rubin  S, Pediatric rheumatic disease in the intensive care unit: lessons learned from 15 years of experience in a tertiary care pediatric hospital. Pediatr Crit Care Med. 2012;13:e1816.DOIPubMedGoogle Scholar
  34. Shulman  AI, Punaro  M. Critical care of the pediatric patient with rheumatic disease. Curr Opin Pediatr. 2011;23:2638.DOIPubMedGoogle Scholar
  35. Thomas  E, Symmons  DP, Brewster  DH, Black  RJ, Macfarlane  GJ. National study of cause-specific mortality in rheumatoid arthritis, juvenile chronic arthritis, and other rheumatic conditions: a 20 year followup study. J Rheumatol. 2003;30:95865.PubMedGoogle Scholar
  36. Hashkes  PJ, Wright  BM, Lauer  MS, Worley  SE, Tang  AS, Roettcher  PA, Mortality outcomes in pediatric rheumatology in the US. Arthritis Rheum. 2010;62:599608.PubMedGoogle Scholar
  37. Lionetti  G, Kimura  Y, Schanberg  LE, Beukelman  T, Wallace  CA, Ilowite  NT, Using registries to identify adverse events in rheumatic diseases. Pediatrics. 2013;132:e138494.DOIPubMedGoogle Scholar
  38. Ringold  S, Hendrickson  A, Abramson  L, Beukelman  T, Blier  PR, Bohnsack  J, Novel method to collect medication adverse events in juvenile arthritis: results from the childhood arthritis and rheumatology research alliance enhanced drug safety surveillance project. Arthritis Care Res (Hoboken). 2015;67:52937.DOIPubMedGoogle Scholar
  39. Ruperto  N, Brunner  HI, Quartier  P, Constantin  T, Wulffraat  N, Horneff  G, ; PRINTO; PRCSG. Two randomized trials of canakinumab in systemic juvenile idiopathic arthritis. N Engl J Med. 2012;367:2396406.DOIPubMedGoogle Scholar
  40. De Benedetti  F, Brunner  HI, Ruperto  N, Kenwright  A, Wright  S, Calvo  I, ; PRINTO; PRCSG. Randomized trial of tocilizumab in systemic juvenile idiopathic arthritis. N Engl J Med. 2012;367:238595.DOIPubMedGoogle Scholar
  41. van Royen-Kerkhof  A, Vastert  BS, Swart  JF, Wulffraat  NM. Biologic treatment of pediatric rheumatic diseases: are we spoilt for choice? Immunotherapy. 2014;6:13.DOIPubMedGoogle Scholar
  42. Wahezi  DM, Ilowite  NT. Juvenile idiopathic arthritis: an update on current pharmacotherapy and future perspectives. Expert Opin Pharmacother. 2013;14:97589.DOIPubMedGoogle Scholar

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1Current affiliation: Leeds General Infirmary, Leeds, UK.

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Page updated: September 15, 2016
Page reviewed: September 15, 2016
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