TY - JOUR AU - Zhu, Wenfei AU - Zhang, Hong AU - Xiang, Xingyu AU - Zhong, Lili AU - Yang, Lei AU - Guo, Junfeng AU - Xie, Yiran AU - Li, Fangcai AU - Deng, Zhihong AU - Feng, Hong AU - Huang, Yiwei AU - Hu, Shixiong AU - Xu, Xin AU - Zou, Xiaohui AU - Li, Xiaodan AU - Bai, Tian AU - Chen, Yongkun AU - Li, Zi AU - Li, Junhua AU - Shu, Yuelong T1 - Reassortant Eurasian Avian-Like Influenza A(H1N1) Virus from a Severely Ill Child, Hunan Province, China, 2015 T2 - Emerging Infectious Disease journal PY - 2016 VL - 22 IS - 11 SP - 1930 SN - 1080-6059 AB - In 2015, a novel influenza A(H1N1) virus was isolated from a boy in China who had severe pneumonia. The virus was a genetic reassortant of Eurasian avian-like influenza A(H1N1) (EA-H1N1) virus. The hemagglutinin, neuraminidase, and matrix genes of the reassortant virus were highly similar to genes in EA-H1N1 swine influenza viruses, the polybasic 1 and 2, polymerase acidic, and nucleoprotein genes originated from influenza A(H1N1)pdm09 virus, and the nonstructural protein gene derived from classical swine influenza A(H1N1) (CS H1N1) virus. In a mouse model, the reassortant virus, termed influenza A/Hunan/42443/2015(H1N1) virus, showed higher infectivity and virulence than another human EA-H1N1 isolate, influenza A/Jiangsu/1/2011(H1N1) virus. In the respiratory tract of mice, virus replication by influenza A/Hunan/42443/2015(H1N1) virus was substantially higher than that by influenza A/Jiangsu/1/2011(H1N1) virus. Human-to-human transmission of influenza A/Hunan/42443/2015(H1N1) virus has not been detected; however, given the circulation of novel EA-H1N1 viruses in pigs, enhanced surveillance should be instituted among swine and humans. KW - viruses KW - influenza virus KW - influenza (H1N1) KW - reassortant virus KW - Eurasian avian-like virus KW - clinical features KW - infectivity KW - virulence KW - China KW - novel KW - human origin KW - influenza A(H1N1) virus KW - influenza KW - genetic reassortant KW - EA-H1N1 KW - novel virus KW - swine influenza virus KW - respiratory infections DO - 10.3201/eid2211.160181 UR - https://wwwnc.cdc.gov/eid/article/22/11/16-0181_article ER - End of Reference